Analgesize it... Which drugs will best cope with pain

A lot of people suffer from pain very often or even constantly. Many people take painkillers almost every day, but rarely does anyone choose them correctly for themselves.

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There are many types of pain for which it is not always convenient to go to the doctor. For example, moderate and occasional pain in muscles and joints, headaches, hangovers, regular pain during menstruation in women. But on the other hand, people get confused. They make the wrong choice by buying a medicine that is not at all ideal for them. Some chose it under the influence of advertising, others on the advice of friends. Many people have their own favorite drug, which has relieved them of pain more than once. And they generously recommend it to others. In this case, as a rule, very powerful analgesics are recommended - it’s like shooting sparrows from a cannon. Such excess medications, while relieving pain, also have a harmful effect; they have many more side effects.

Comparison of the effectiveness of Baralgin M and Tempalgin

Tempalgin is more effective than Baralgin M - this means that the ability of the drug substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of Tempalgin is more pronounced, then with Baralgin M it is impossible to achieve this effect even in large doses.

Also, the speed of therapy is an indicator of the speed of the therapeutic action; Tempalgin and Baralgin M are also different, as is bioavailability - the amount of the drug reaching the site of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.

Table: Instructions for assembling medicines

Comparison of safety of Baralgin M and Tempalgin

The safety of a drug includes many factors.

At the same time, in Baralgin M it is quite similar to Tempalgin. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Baralgin M, as well as Tempalgin, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Baralgin M does not have any risks when used, just like Tempalgin.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Baralgin M and Tempalgin.

Herpes: what is it and what medications to use?

Herpes means “crawling” in Greek. At the moment, the relevance of this disease has not decreased. It occurs in more than 90% of the population.

What is herpes

Most often, problems are caused by herpes simplex virus types 1 and 2. Type 1 is herpes on the lips, eyes and mouth. Type 2 is genital herpes and herpes of pregnant women and newborns.

How to understand that it is herpes?

Let's take for example the most commonplace herpes on the lips. The first thing a person feels is itching in the lip area (often it may not be noticed during the day). On the same day, redness and red spots appear. The next day, a blister and swelling appear at the site of redness. After 3-5 days, a crust forms at the site of the burst blisters. After 7-9 days, all symptoms disappear. Also, during the stage with blisters, the temperature may rise to 37.5-38.5°C and pain may appear.

But to reliably confirm the diagnosis, a blood test is required to determine the presence of a specific reaction of the body to the virus (IgM); it will indicate that at the time of donating blood you are experiencing an acute period of illness.

For genital herpes, discharge from the genital tract and urethra is also taken for examination. Consultation with a specialist (dermatovenerologist) is required.

It is worth noting that the virus is not eliminated from the body after chickenpox, but remains to “live” in a certain part of our nervous system, so taking an Ig G test does not make sense.

How can you get infected?

Infection occurs through mucous membranes:

• lips
• Rta
• Nose
• Genitals
• Eyes
• Through the skin in contact with biological fluids (saliva, urine, semen, tears, nasal discharge, direct fluid from the herpes vesicle).

That is, most often infection occurs due to poor hygiene and protection during sexual intercourse. Also, when scratching the blisters that have already appeared, they spread to new areas of the skin and mucous membranes.

A separate route of infection from mother to fetus, currently testing for HSV-1.2 is mandatory in women planning pregnancy and pregnant women.

The infection affects the nervous system and has dangerous consequences for the body.

How to behave with herpes

• Do not touch the rash with your hands; if you touch it, wash your hands immediately.
• Use separate dishes, cosmetics, and towels.
• Refrain from kissing and sexual contact.
• Apply medicated gels and ointments with a cotton swab, not with your hands.

Be sure to treat!

To reliably confirm the diagnosis, it is necessary to undergo an analysis.

Drugs

Let us consider in detail the groups of drugs for treatment

1. Antiviral:

• Zovirax
• Valtrex
• Famvir
• Groprinosin

This group of drugs acts directly on the cause, the virus itself. The course and dosage regimen are prescribed by the doctor after a comprehensive examination.

The drugs are well tolerated; they are contraindicated during pregnancy and breastfeeding. Use with caution and under medical supervision in persons with renal and hepatic insufficiency. For children, the dose is determined by the pediatrician based on weight.

2. Interferon preparations:

• Viferon
• Kipferon
• Reaferon EC lipint

When you get a herpes infection, there is a decrease in the production of your own interferon alpha, which means a decrease in the body's defenses against the virus.

This group has practically no contraindications. It is the main method of treating such a vulnerable group as pregnant and lactating women.

1. Interferon inducers:

• Amiksin
• Cycloferon
• Anaferon

Used to stimulate the production of your own interferon and avoid aggravation of the course and spread of infection. Well tolerated. Contraindications for each drug are for a certain age indicated in the instructions.

1. Local antibacterial and antiviral drugs:

• Grammidin
• Lysobacter
• Hexoral

These drugs are used for herpetic lesions of the oral mucosa, have an antibacterial, antiviral effect, and also relieve inflammation and relieve pain.

• Zovirax ointment and Zovirax Duo active
• Viferon
• Infagel
• Panavir

They have a local antiviral effect, Zovirax Duo Active in combination with the hormone hydrocortisone provides rapid relief from inflammation and, accordingly, pain, and also prevents the formation of new blisters. But since it contains a hormonal component, you need to read the instructions very carefully. Only from 12 years old. Before using any ointments and gels, it is necessary to cleanse the skin of cosmetics and impurities.

1. Immunomodulators under the control of an immunogram:

• Polyoxidonium
• Lycopid

Only under the supervision of an immunologist.

1. Painkillers:

• Nurofen
• Panadol

Relieves pain, inflammation and, if necessary, temperature.

1. Antihistamines:

• Zodak
• Claritin

Helps avoid swelling.

1. Vitamin complexes:

• Vitrum
• Complivit
• Selenium
• Zinc
• Vitamin C

You can also separately select a vaccine against herpes. It is indicated for adults who suffer from herpes more than 3 times a year and a high titer of antibodies, elderly people, and HIV-infected people. Also for children who have not had chickenpox.

Treatment for pregnant women is selected depending on the duration of pregnancy, strictly by an obstetrician-gynecologist and depends on the severity of the course!

Herpes is a complex problem. The cause of recurring or new herpes is a decrease in immunity and hormonal changes.

The main prevention is to maintain the functioning of the immune system:

• Complete nutrition
• Sufficient amount of meat, fish and vegetables.
• Taking complex vitamin preparations containing necessarily: zinc, vitamin A, E, C.
• It is necessary to monitor the level of iron in the blood.
• The largest organ of our immune system is the intestines; it is necessary to support its functioning and, if necessary, take pro- and prebiotics.
• Have a regular sexual partner and observe good hygiene.
• In case of frequent recurrence of infection, vaccinate during periods of “quiet” periods.
• People with systemic diseases (diabetes mellitus types 1, 2, etc.) need to control and maintain the underlying disease in the compensation stage.

Literature:

Federal clinical guidelines for the management of patients with genital herpes - Moscow 2015; Clinical guidelines for herpes simplex in adults - 2014;

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Comparison of addiction between Baralgin M and Tempalgin

Like safety, addiction also involves many factors that must be considered when evaluating a drug.

So, the totality of the values ​​of such parameters as “syndrome o” in Baralgin M is quite similar to the similar values ​​in Tempalgin. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, in Baralgin M the meaning of the “syndrome” is quite small, however, the same as in Tempalgin.

The Fab Five?

Let's take a closer look at the strengths and weaknesses of each of these drugs. There will be no shortage of incriminating evidence against them - competition among painkiller manufacturers is very high and they are constantly at war with each other.

Acetylsalicylic acid. Helps with almost all pains, acting for 3-6 hours. One of the most popular medicines, used for more than 100 years, and one of the most reviled - it can cause gastritis, ulcers and even bleeding from the stomach. How should we feel about this? If you had such complications before, you should not take ASA. Occasional use is unlikely to be aggressive for the stomach. There is no need to take ASA on an empty stomach and do not exceed a single dose of 600–750 mg. ASA is contraindicated for children under 14 years of age: it is believed that it sometimes causes Reye's syndrome in children, a very rare but serious and dangerous disease.

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Ibuprofen. It is gentler on the stomach than ASA. The pain relief time is also slightly longer – 4–8 hours. But ASA is better for the heart; frequent use of ibuprofen by heart patients increased their risk of heart attacks and strokes by almost 2 times. Many of them take low doses of ASA for prevention, and ibuprofen blocked its effect. Therefore, it is better to take it by young people rather than older people.

Naproxen. It is similar to ASA and ibuprofen, and the side effects of these drugs are common. In terms of the degree of aggressiveness to the stomach, it occupies an intermediate position between these drugs. It relieves pain well and lasts longer, so you need to take it 2 times a day, maximum 3 times.

By the way: all these three drugs have a triple effect. They not only relieve pain, but also lower the temperature. In addition, they have an anti-inflammatory effect. Because of the latter effect, they are also used for rheumatic diseases, for which inflammation and pain in the joints are typical. The other two analgesics (metamizole, paracetamol) do not have this effect; they are used only for pain and to reduce high fever.

Metamizole (analgin). They scold the drug no less than ASA, claiming that it is banned almost everywhere due to the fact that it inhibits the formation of white blood cells (agranulocytosis). This is a very strong exaggeration: the drug fell victim to pharmaceutical wars in only a few countries, and it causes this complication in one case in a million. In addition, almost all painkillers and a bunch of other drugs are to blame for this.

Paracetamol. They always say about it that, unlike ASA and ibuprofen, it does not irritate the stomach. This is true, but it is difficult to find another medicine that would be so insidious towards the liver. There are cases when a therapeutic daily dose of paracetamol of 4 g turned out to be fatal for this organ. The drug is especially dangerous for those who already have a diseased liver or who drink moderately (the critical daily dose is 3 small glasses of vodka or 3 glasses of wine). In no case should you relieve a hangover with this medicine, trying to eliminate the headache, and in no case should you exceed the dose. It is better not to take more than 0.5 g at one time. And if paracetamol is taken with other medications, you must definitely check their composition. This substance is so often used in complex preparations that it is easy to overdose.

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Comparison of side effects of Baralgin M and Tempalgin

Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.

Baralgin M has almost the same level of adverse events as Tempalgin. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Baralgin M are similar to Tempalgin: how quickly the body recovers after taking it and whether it recovers at all.

Pharmaceutical constructor

How to cope with pain and not harm your health? Let's try to understand analgesics and bring all the many of these drugs into the system. It's not difficult at all. The abundance of these drugs appearing under different brand names is deceptive. Why?

Firstly, because they are all made according to the principle of a construction set, which has much fewer parts than your child’s Lego (see table). That is, there are few “parts”, but a lot of medicines are collected from them.

Question answer

How often can you take painkillers for headaches?

Secondly, there are even fewer main “parts” that have an analgesic effect. These are acetylsalicylic acid (ASA), metamizole, paracetamol, ibuprofen and naproxen - only these 5 active substances can be found in over-the-counter tablets, capsules, suspensions and other forms of medications for oral administration. And one or two of these components are found in any over-the-counter analgesic. Based on these five “parts,” hundreds of analgesics are made, sold without a prescription under various brand names. For example, there are several dozen paracetamols alone, the most advertised being Panadol, Calpol, Efferalgan. Of the drugs with ASA - aspirin and upsarin, of the ibuprofens - Nurofen and Burana, the drugs of metamizole - this is the familiar analgin, of the drugs with naproxen - Nalgesin, Motrin, etc. But in general there are many such monopreparations containing only one of the five components more.

Important: drugs consisting of one “part” are safer than complex drugs: fewer “parts” mean fewer side effects. But their strength is usually enough to cope with ordinary pain.

Comparison of ease of use of Baralgin M and Tempalgin

This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.

The ease of use of Baralgin M is approximately the same as Tempalgin. However, they are not convenient enough to use.

The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.

Last update date: 2020-12-04 13:44:51