Nimesulide in the treatment of chronic joint diseases

Compound similarities

These drugs have the same release form - water-soluble powder. Their therapeutic effects are similar. Both drugs effectively reduce temperature and eliminate pain.

Nemulex contains the active substance – nimesulide.

Additional components:

• macrogol;
• sucrose;
• flavoring agents;
• citric acid;
• silicon.

The medicine has analgesic, anti-inflammatory, antipyretic, and antiaggregation properties. The product has good digestibility. The medicine remains at its highest concentration in the blood for 2.5 hours.

The drug quickly enters the lesion and is excreted by the liver and kidneys. Nemulex suppresses prostaglandins in the inflammatory focus. The medicine is used to treat negative symptoms. The medication eliminates pain and prevents the development of inflammation.

Indications for use:

• arthritis;
• muscle pain;
• joint pain;
• bursitis;
• tenosynovitis;
• pain during menstruation;
• headache;
• toothache;
• pain syndrome during the development of intervertebral hernia;
• pain after injuries and operations.

The product does not have a therapeutic effect, but eliminates pain and inflammation of an episodic nature.

Indications for use of Nemulex: arthritis, muscle pain, joint pain.

Nimesil is produced in the form of granules for oral administration and suspension. The active substance is the same - nimesulide.

Additional components:

• macrogol;
• maltodextrin;
• lemon acid;
• sucrose;
• flavorings.

The medicine is a non-hormonal anti-inflammatory drug. It has anti-inflammatory, antipyretic and analgesic properties.

The drug reduces the synthesis of prostaglandins by inhibiting cyclooxygenase. After oral administration, the drug is well absorbed, reaching its highest concentration in the blood after 2-3 hours. The drug is metabolized in the liver.

Indications for use:

• elimination of pain syndrome;
• relief from primary dysmenorrhea.

What to do if your tooth hurts: TOP 6 best painkillers for toothache

There are two groups of drugs that are best used to relieve toothache. These include: analgesics and NSAIDs (non-steroidal anti-inflammatory drugs).

Analgesics for toothache

These medications eliminate the source of pain by affecting the nerve endings and pain centers in the brain. However, analgesics, unlike NSAIDs, do not affect inflammatory processes and cannot eliminate inflammation of the pulp, periosteum, and gums.

Some drugs from this group, in addition to the analgesic effect, also have an antipyretic effect - they are called analgesics-antipyretics. Such medications can eliminate toothache and reduce the fever that accompanies it. Thus, analgesics-antipyretics help get rid of two unpleasant symptoms at once.

Paracetamol is considered the most popular and safe drug from this group.

Paracetamol

This medication has analgesic and antipyretic properties. It begins to act 30 minutes after administration, after the same time the maximum concentration of the active substance in the body is reached. Paracetamol can be used by children over 6 years of age (in tablet form, dosage 200 mg), adults, pregnant and lactating women.

The effect of the drug lasts 4 hours. This remedy can also be combined with other drugs to enhance their effectiveness. Paracetamol is quite safe, as it has a small list of side effects, and cases of their occurrence are recorded extremely rarely.

Contraindications for use:

• chronic alcoholism;
• serious liver disorders;
• hypersensitivity to paracetamol.

If you have a toothache and this causes your temperature to rise, then the safest thing to do is take a drug whose main active ingredient is paracetamol.

NSAIDs for toothache

Non-steroidal anti-inflammatory drugs suppress the production of prostaglandins (hormone-like substances that cause pain and inflammation in the body), resulting in reduced pain and inflammation. In addition, drugs from this group also have an antipyretic effect.

However, they cause a large list of side effects for the gastrointestinal tract and cardiovascular system. Therefore, they must be taken according to the instructions and prescription of the doctor. It is important to note that medical experts do not recommend taking non-steroidal anti-inflammatory drugs on an empty stomach, as this can lead to negative consequences.

There is a list of contraindications for which NSAIDs should not be taken:

• combined use with other drugs from the NSAID group;
• allergic reactions to the active and auxiliary substances of non-steroidal anti-inflammatory tablets for toothache, as well as powders, ointments and suspensions;
• severe renal, liver or heart failure;
• diseases of the gastrointestinal tract (ulcers, gastritis, Crohn's disease, ulcerative colitis) in the acute stage;
• previous heart surgeries and progressive diseases of the cardiovascular system;
• existing or recent internal bleeding;
• blood clotting disorders.

If you have a toothache and there are no contraindications listed above, then you can take an NSAID tablet.

The most effective painkillers for toothache from the group of non-steroidal anti-inflammatory drugs include: Nurofen, Nimesil, Ketanov, Dexalgin and Olfen.

Nurofen

Used to relieve mild to moderate toothache. The main active ingredient is ibuprofen, its maximum concentration in the blood plasma is reached after 45 minutes if taken on an empty stomach, or after 2 hours if taken on a full stomach.

After oral administration, ibuprofen is quickly absorbed and begins to relieve pain, relieve inflammation and reduce temperature. The half-life of the drug lasts 2 hours.

In addition to the standard contraindications for NSAIDs, ibuprofen should also not be used by women in the last trimester of pregnancy, as this can negatively affect the health of the baby.

Nurofen in tablet form for toothache can be taken by children over 6 years old if their body weight exceeds 20 kg.

To avoid negative reactions from the stomach and the entire gastrointestinal tract, it is recommended to take the drug after meals.

Ibuprofen tablets, which are film-coated, reduce the risk of side effects from the digestive system.

Nimesil

The main active ingredient of the drug is nimesulide. Nimesil is a light yellow powder that has a pronounced citrus smell.

When taken orally, nimesulide is quickly absorbed from the stomach and enters the bloodstream, and the maximum plasma concentration of 100 g of this active substance is achieved 2-3 hours after administration.

It is recommended to take Nimesil for toothache after meals. Nimesulide powder should be poured into a glass, pour 100 ml of water, stir and drink.

An additional contraindication to its use, in addition to the general contraindications for the NSAID group, is the combined use of nimesulide with analgesics and the presence of infectious fever.

It should not be taken by children under 12 years of age, pregnant or nursing mothers, or people with kidney or liver disease.

Ketanov

This drug is used against severe and moderate toothache. Its main active ingredient is ketorolac tromethamine. Ketanov is not addictive, and the strength of its analgesic effect is compared to morphine. This drug is much stronger and more effective than other members of the NSAID group.

Ketanov for toothache has an effect 60 minutes after a person takes the tablet, and the maximum effect of the drug appears after 2-3 hours.

The medication should be taken on a full stomach, because taking the painkiller on an empty stomach increases the risk of side effects. A few hours before and after taking Ketanov, it is recommended not to eat fatty foods, as it slows down the speed of its action.

It should be noted that the presence of urticaria, bronchial asthma, cerebrovascular bleeding and tonsillitis in a person is considered contraindications to the use of the drug.

Children are allowed to drink Ketanov for severe toothache only from the age of 16, and it is not prescribed to lactating women, pregnant women and people with chronic heart, kidney and liver diseases.

Dexalgin

The main component is dexketoprofen. Dexalgin relieves toothache 30 minutes after oral administration. The duration of the analgesic effect is 4-6 hours, and the duration of removal of the medication from the body is 1-3 hours.

Dexalgin is contraindicated for use in patients with bronchial asthma and hemorrhagic diathesis. In addition, it is strictly prohibited for children, women during lactation, pregnant women to drink it and should be taken with caution by people over 65 years of age. And patients who have problems with the kidneys and liver need to reduce its minimum dosage.

Dexalgin must be prescribed by a doctor, since this medicine, like all NSAID drugs, is available by prescription.

Olfen

The main active ingredient is diclofenac. It inhibits the biosynthesis of prostaglandins, thereby suppressing toothache and inflammation. It can also reduce elevated body temperature.

Contraindications to the use of Olfen are:

• cardiac ischemia;
• angina pectoris or previous myocardial infarction;
• peripheral artery disease;
• cerebrovascular pathologies.

The effect begins to appear 30 minutes after administration, and the maximum concentration in the blood occurs after 120 minutes.

Olfen is available by prescription after being prescribed by a doctor.

Differences between Nimesil and Nemulex

Despite the fact that these drugs are analogues, they also have differences.

Main differences:

• the price of Nemulex is less than Nimesil;
• they are made by various manufacturers;
• the taste and smell of the powder differs;
• Nemulex granules are larger than Nimesil;
• Nemulex in powder form often takes longer to dissolve in water.

But these differences are not significant; they do not affect the effectiveness of the drugs. Thus, apart from the price and slight differences in the composition of the components, these drugs do not differ in anything else. Both medications effectively eliminate pain and alleviate the patient's condition.

These medications should not be taken together, because they both contain the active ingredient nimesulide, and if taken at the same time, there may be an overdose that will cause side effects.

Both drugs have the same indications for use:

• osteoarthritis;
• arthritis;
• myalgia;
• arthralgia;
• headache and toothache.

Kinds

A veterinarian should prescribe pain medication for your cat. Only a specialist can assess the need for analgesic therapy and select the type, brand and dosage of the medication. When prescribing, the biometric characteristics of the pet (weight, age, gender), its health and physiological condition must be taken into account.

In cat veterinary medicine, a limited list of drugs is used.

Most analgesics used to treat humans, dogs, and large pets are toxic to cats.

Types of drugs used in cats:

1. Opioids. Narcotic drugs.
2. Non-steroidal anti-inflammatory drugs.
3. Local anesthetics.
4. Alpha2-adrenergic agonists (alpha2-adrenergic receptor agonists).
5. NMDA receptor antagonists.
6. Anticonvulsants.

Contraindications

Nemulex and Nimesil have the following contraindications:

• intolerance to the components of the drug;
• bronchospasm;
• alcoholism;
• gastrointestinal bleeding;
• stomach and duodenal ulcers;
• cerebrovascular bleeding;
• increased bleeding;
• bleeding disorders;
• severe heart failure;
• liver and kidney dysfunction;
• flu;
• high body temperature;
• children under 12 years of age;
• pregnancy in the third trimester;
• lactation;
• hyperkalemia;
• if the patient has undergone coronary artery bypass surgery;
• diabetes.

Nimesil has the following contraindications: intolerance to the components of the drug, bronchospasm.

These drugs should not be used simultaneously with antiplatelet agents, glucocorticosteroids and anticoagulants.

How to take Nimesil and Nemulex

Nemulex is taken as follows. It is necessary to dissolve the contents of the package in 0.5 cups of boiled water. For adult patients and children over 14 years of age, take 100 mg 2 times a day. The medicine is taken after meals. The course of treatment should last no more than two weeks.

Nimesil is taken in a short course. The product is drunk after meals. The course of treatment should not last more than 14 days. For adults, 100 ml of the active substance (1 sachet of powder) is prescribed 2 times a day. Children and the elderly are prescribed the same dosages. Before taking the medicine, you need to pour the contents of the sachet into a glass of water, dissolve and drink the product.

Side effects of drugs Nimesil and Nemulex

Side effects of Nemulex are:

• nausea;
• vomit;
• sleep disorders;
• increased blood pressure;
• dyspnea;
• stomach bleeding;
• depression.

Side effects of Nimesil:

• nausea;
• vomit;
• pain in the epigastrium;
• sleep disorders;
• gastrointestinal bleeding;
• arterial hypertension;
• acute renal failure;
• breathing problems;
• anaphylaxis.

Adverse reactions

Taking the drug may cause side effects such as diarrhea or constipation, which disappear when you stop using the drug.
It is necessary to distinguish between the side effects of the drug and the complications caused by it. In option 1, the disorders go away on their own when you stop taking the medication, but complications require medical intervention. Adverse reactions from the gastrointestinal tract, such as nausea, vomiting, bloating, constipation or diarrhea, and black stools, are more common. Therefore, if you decide to give your pet Nimesil, mandatory monitoring of the animal’s condition and behavior is required.

Reviews from doctors

Svetlana Anatolyevna, therapist

These drugs are prescribed when the patient urgently needs relief from pain. Medicines effectively eliminate headaches, toothaches, and pain during menstruation. Patients tolerate these medications well, but they cannot be taken for a long time. The course of treatment should not last more than two weeks.

Arkady Mikhailovich, rheumatologist

In patients with rheumatoid arthritis, when the disease worsens, joint pain intensifies and the inflammatory process worsens, these drugs are prescribed. They effectively cope with pain and inflammation.

In what cases is it used?

Nimesil is used to eliminate pain in a pet as a result of severe injuries.
The medication is widely used to treat inflammatory processes of the musculoskeletal system, for urological and gynecological problems, in traumatology, and for fever of various etiologies. Veterinarians use Nimesil for cats in case of severe injuries, increased body temperature of animals, dental, postoperative and other types of pain.

Patient reviews

Alla, 35 years old

If pulpitis occurs, the doctor recommended taking Nimesil. He quickly eliminated severe toothache. The next day, when the severe pain had already disappeared, I went to see a dentist to treat a bad tooth.

Sergey Ivanovich, 60 years old

I have been suffering from osteoarthritis of the knee joints for several years. When the disease worsens, severe pain occurs and it becomes impossible to walk. In this case, the doctor advised taking Nemulex. I take the drug according to the instructions prescribed by the doctor. After a few days, the pain subsides.