Amoxicillin

Inside, before or after meals.

Adults and children over 10 years of age (weighing more than 40 kg) are prescribed 250 mg 3 times a day; for severe infection - 500 mg 3 times a day.

For children under 10 years of age, the drug is prescribed in the form of a suspension, since at this age dosing the drug in capsules is difficult.

The interval between each dose of 8 hours must be strictly observed.

The maximum daily dose should not exceed 6 g.

The course of treatment is 5-12 days. It is recommended to continue treatment for 48-72 hours after body temperature has returned to normal or after the pathogen has been effectively destroyed.

Infections of the upper respiratory tract and ENT organs (sinusitis, pharyngitis, tonsillitis, acute otitis media): 250 mg every 8 hours.

Lower respiratory tract infections (acute and chronic bronchitis, pneumonia): 500 mg every 8 hours.

Acute uncomplicated infections of the genitourinary system: high-dose therapy is recommended: 2 doses of 3 g each with an interval of 10-12 hours.

For acute uncomplicated gonorrhea, men are prescribed 3 g once; when treating women, it is recommended to take the indicated dose twice with an interval of 10-12 hours due to the possible multiple nature of the lesion and an ascending inflammatory process with transition to the pelvic organs.

Gynecological infections without fever: 250 mg every 8 hours.

Gynecological infections accompanied by fever: 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

Infections of the gastrointestinal tract (enterocolitis, typhoid fever, shigellosis): 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

Salmonella carriage: 1.5-2 g 3 times a day for 2-4 weeks.

Peptic ulcer of the stomach and duodenum, chronic gastritis associated with Helicobacter pylori as part of combination therapy: 1 g 2 times a day.

Biliary tract infections (cholangitis, cholecystitis): 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

Skin and soft tissue infections (erysipelas, impetigo, secondary infected dermatoses): 250 mg every 8 hours.

Leptospirosis: 500 mg-750 mg 4 times a day for 6-12 days.

Lyme disease (borreliosis): for stage I of the disease, 500 mg 3 times a day.

Infectious endocarditis, for example, enterococcal: for the prevention of endocarditis during minor surgical interventions in adults - 3-4 g 1 hour before the procedure. If necessary, a repeat dose is prescribed after 8-9 hours.

Patients with severe renal impairment should reduce the dose or increase the interval between doses of amoxicillin.

When creatinine clearance is below 10 ml/min and for patients on peritoneal dialysis, the maximum daily dose is 500 mg (250 mg 2 times a day); with a creatinine clearance of 10-30 ml/min, the maximum daily dose is 1000 mg (500 mg 2 times a day); if creatinine clearance is more than 30 ml/min, no dosage adjustment is required; for anuria - the maximum dose should not exceed 2 g/day.

For children aged 5-10 years, the dose is calculated per kilogram of the child’s weight. In pediatric practice, Amoxicillin in capsule form is applicable if the daily dose is at least 500 mg taken twice a day (250 mg 2 times a day).

For a child weighing less than 20 kg, the daily dose is 25 mg/kg/day, divided into 3 doses; for severe disease - 50 mg/kg/day, divided into 3 doses.

For a child with a body weight in the range of 20-40 kg, amoxicillin is prescribed at a dose of 40-90 mg/kg/day in 3 divided doses at low doses and in 2 divided doses at high doses.

For children weighing more than 40 kg, the drug is prescribed based on the dosage regimen for adults.

Tonsillitis: 50 mg/kg/day in 3 divided doses.

Acute otitis media: in severe cases and relapses, 750 mg 2 times a day for 2 days can be used as an alternative treatment regimen.

Prevention of endocarditis: 1.5 g 1 hour before surgery as a single dose. For surgical interventions performed under general anesthesia - 1.5 g 4 hours before surgery as a single dose. If necessary, re-administer after 6 hours.

For children with impaired renal function with creatinine clearance less than 10 ml/min, the interval between doses should be increased to 24 hours, which corresponds to taking 1/3 of the usual dose; with creatinine clearance in the range of 10-30 ml/min, the interval between doses is increased to 12 hours, which corresponds to taking 2/3 of the usual dose; When creatinine clearance is more than 30 ml/min, no dosage adjustment is required.

If you miss a dose of the drug, you should take the capsule as soon as possible without waiting for the next dose, and then maintain equal intervals between doses.

Medical treatment of acne and seborrhea

There are skin diseases that are treated by both dermatologists and cosmetologists. These include things that everyone may have, that you may not pay attention to, but that you really want to get rid of, since it affects the aesthetic appearance of the skin. So, these are problems that spoil the appearance and cause not so much physical as mental suffering. We will focus here only on the most common ones - Acne, seborrhea and various formations on the skin.

Acne vulgaris or juvenile acne

Acne

– the most common skin disease in adolescents and young people, that is, the most socially active part of the population. This unpleasant disease affects about 85% of people aged 12 to 25 years in European countries, so clear skin at this age is the exception rather than the rule. The presence of inflamed pimples, pustules and ulcers, blackheads (comedones), spots and scars, a greasy, untidy appearance of the skin in the most visible places causes difficulties in communication, professional organization, reduces self-esteem, and often leads to the formation of significant psycho-emotional disorders, even the desire for complete isolation. Some young people stop leaving home, give up school and work, become isolated, and eventually a minor and completely banal skin problem develops into a personal tragedy. A patient who consults a dermatologist about acne has serious psychological problems. Shyness, guilt, a sense of social unacceptability, anger, depression, and disbelief in the possibility of a cure are expressed to varying degrees. Intense experiences aggravate the course of the disease. In stressful situations, patients, especially women, pick at the skin and squeeze out acne, which further worsens the appearance of the skin due to associated inflammation. In such injured areas, scars and spots remain that do not go away for a long time.

Acne

– a long-term disease, often exacerbating (in girls, usually monthly) and often resistant to treatment. Currently, we know much more about acne than ten years ago, and a competent specialist can always help a patient. In this regard, the opinion that existed in the past that acne will go away on its own with age, and therefore there is no need to waste effort on treating it, now sounds simply absurd. It is not always possible to immediately find the right individual approach, but the efforts made and perseverance shown are always rewarded with a good result. Specialists have a number of effective medications from different groups in their arsenal. The choice of drug depends on the form of the disease, the predominance of certain symptoms, the gender of the patient, and the presence of contraindications.

Acne is most often divided into:

acne with a predominance of comedones (white and blackheads with mild inflammation);
papulopustular acne (there are comedones, inflamed nodules - what are usually called pimples, pustules, sometimes single large painful lumps, gradually turning into ulcers such as boils);
conglobate acne (along with all of the above, there are long-term painful lumps that leave pronounced scars after healing).

Over time, most patients develop the habit of squeezing out comedones and pustules, constantly touching the inflamed skin, which is why bloody crusts, spots, and superficial scars are added to everything described.

Many factors take part in the development of acne, the action of which is ultimately realized in the pilosebaceous follicles. Not all follicles are affected, but only those with a special structure, located on the face and in the upper part of the body, with large sebaceous glands, wide (up to 2.5 mm) ducts and thin, almost invisible hairs. The sebaceous glands are the target organ for sex hormones, especially testosterone. Under the influence of testosterone, produced by the gonads especially actively in adolescence, the size and number of sebaceous glands increase significantly, the production of sebum increases, and its composition changes. In addition, in the development of acne, disruption of the keratinization of the sebaceous gland ducts, difficulty in the outflow of sebum to the surface of the skin, increased proliferation of microbes in accumulated sebum and subsequent inflammation are essential. With the help of modern medicines it is possible to influence almost all factors involved in the development of the disease.

At the initial manifestations of acne (usually at the age of 8–13 years), when the clinical picture is dominated by increased oily skin and comedones (whitish nodules and blackheads), and there are not many inflammatory elements, preparations of retinoic and salicylic acids are used externally. Both acids have the property of dissolving comedones, and salicylic acid has a much weaker effect in this regard. For papulopustular acne, it is advisable to use antibiotics, retinoids, benzoyl peroxide (benzoyl peroxide), traditional external agents (salicylic, chloramphenicol, resorcinol alcohols). Severe forms of acne, including conglobate acne, should be treated with retinoids prescribed orally, and only if there are contraindications, other treatment methods (antibiotics, immunomodulators) should be used. As with papulopustular acne, it is preferable to use a combination of different drugs.

Problems solved during the treatment process and ways to solve them:

reduction in sebum production (retinoids, especially retinoic acid, hormonal drugs - estrogens, progestins or antiandrogens, spironolactones);
reduction of inflammation - antibiotics (tetracyclines, erythromycin, lincomycin, clindamycin) and local anti-inflammatory and microcirculation-improving agents, including zinc oxide, sulfur, tar, ichthyol, resorcinol;
prevention of the appearance and elimination of comedones (retinoids, especially retinoic acid, salicylic alcohol);
preventing the appearance of scars (early initiation of treatment, retinoids, curiosin, contractubex, avoiding trauma to rashes).

Features of acne treatment with drugs of different groups

Currently, retinoids are the most effective group of drugs for the treatment of acne. Their use solves several problems at once - reducing sebum production and inflammation, preventing the appearance and elimination of comedones and scars. Two isomers of retinoic acid (tretinoin and isotretinoin) are used for external treatment of acne. Roaccutane and Retinol palmitate are used for internal treatment of conglobate acne and common papulopustular acne resistant to other external agents.

Roaccutane (isotretinoin) (Hoffmann-La Roche, Switzerland) is available in capsules for oral use of 10 and 20 mg (30 pieces per package). Prescribed at the rate of 0.5–1.0 mg/kg body weight per day, taken in equal parts 2 times a day after meals for 12–16 weeks. If repeated courses are necessary, the break should be at least 8 weeks. Roaccutane is a highly effective drug, however, its use is limited by high cost and many side effects. Treatment is always carried out under the supervision of a specialist.

Retinol palmitate

(vitamin A) is a domestic drug, it is produced in capsules for oral use at 33,000 and 100,000 IU, as well as in an oil solution at 100,000 IU/ml. Effective doses for acne are at least 300,000 IU per day. The course of treatment is 12–16 weeks. The intervals between courses are 4–8 weeks. Retinol palmitate is inferior in effectiveness to Roaccutane, however, it is better tolerated and the cost is much lower.

For external treatment of acne, preparations containing all-trans retinoic acid (tretinoin) and 13-cis-retinoic acid (isotretinoin) are used. All-trans retinoic acid is contained in the following foreign preparations: Retin-A – 0.05% cream in tubes of 30 g (Silag, Switzerland), Lokatsid – 0.05% cream in tubes of 30 g and 0.1% solution in 15 ml bottles (“Pierre Fabre”, France). External preparations with 13-cis-retinoic acid, which has higher bioavailability, are produced only in Russia - Retinoic ointment 0.1% and 0.05% and Retasol® (FNPP "Retinoids"). It is recommended to apply ointments and solution to previously cleansed skin 1-2 times a day. Once the effect is achieved, it is recommended to reduce the concentration or reduce the frequency of application of the drug. Duration of treatment is 12–16 weeks.

Drugs from the retinoid group have a number of side effects. The most serious of them are teratogenicity and embryotoxicity. In this regard, women of childbearing age are prescribed retinoids with reliable contraception and a negative pregnancy test. In the outpatient card, when prescribing systemic treatment, a note is usually made about the woman’s awareness of possible side effects, and abroad dermatologists offer women to fill out and sign a special form in order to avoid further prosecution in the event of side effects. External treatment with drugs of this group is stopped when pregnancy occurs. Retinoids do not have a negative effect on the reproductive function of men.

In the first or second week of treatment, most patients experience an exacerbation reaction, expressed in redness, moderate itching, and peeling of the skin. The patient should be warned about the reaction, and if he is facing important life events at this time, then it is better to postpone the start of treatment. Typically, these phenomena go away on their own within a few days, after which a lasting improvement occurs. Dry lips, cracks in the corners of the mouth, peeling of the skin are common during the treatment process; they are eliminated by using a neutral moisturizing cream for the face and body, hygienic lipstick or lip gel, and limiting the use of detergents when washing and washing. With systemic administration of retinoids, dry nasal mucosa, nosebleeds, conjunctivitis, urethritis, increased levels of transaminases and lipids in the blood, and increased sensitivity of the skin to sunlight are sometimes observed. Taking this into account, before the start of treatment and monthly during treatment, a biochemical blood test is performed, it is recommended to use sun protective creams, and avoid direct sunlight.

Contraindications

pregnancy and lactation, abnormalities in biochemical blood tests (hyperlipidemia, increased activity of ALT, AST and alkaline phosphatase), renal and liver failure, hypervitaminosis A, drug intolerance. Retinoids cannot be prescribed simultaneously internally and externally, ultraviolet irradiation, drugs with keratolytic and exfoliating effects, exfoliating cosmetic procedures and products (scrubs, peeling). The effect of retinoids is weakened by the simultaneous use of glucocorticosteroid drugs and alcohol intake.

Antibiotics

Of the wide range of antibiotics used to treat acne, only tetracyclines, erythromycin, lincomycin, josamycin and clindamycin are used. Prescription of antibiotics orally is indicated when a large area of skin is affected, with a predominance of pustules. During pregnancy, only erythromycin can be used among these drugs.

Antibiotics of the tetracycline group have an advantage over other groups, since they are lipophilic and easily reach the main object of their action - the sebaceous glands. They can be prescribed for a long time - 2-3 months in a small dose. In this case, they block the production of bacterial lipases, the main link in the development of inflammation. A significant advantage of this method is the possibility of long-term treatment without disturbing the composition of the intestinal flora. The daily dose of tetracycline is 1000 mg (10 tablets of 0.1 g or 4 tablets of 0.25 g), doxycycline hydrochloride is 50 mg (1 capsule of 0.05 g once a day), Unidox Solutab is 50 mg ( 1/2 tablet of 0.1 g), metacycline - 600 mg (2 times a day, 0.3 g). Antibiotics of the tetracycline group in the indicated doses are always well tolerated, and side effects characteristic of long-term use at a bacteriostatic dose do not develop. Tetracyclines are contraindicated in concomitant fungal diseases, pregnancy (last trimester), liver dysfunction, leukopenia, children under 8 years of age, and kidney disease. During treatment, insolation is not recommended, ultraviolet irradiation, retinoids for internal use, hormonal contraceptives, psychotropic, anticonvulsant and antidiabetic drugs are not prescribed. Absorption of tetracycline is weakened in the presence of food, especially milk and fermented milk products, as well as trace elements - aluminum, calcium, magnesium, iron. Their use should be avoided during treatment. Tablets are taken separately from meals.

Doxycycline, Metacycline and Unidox Solutab are better absorbed and can be taken with or after meals with plenty of water. Unfortunately, microorganisms quickly develop resistance to drugs in this group, and when re-prescribed they are rarely effective.

Erythromycin belongs to the group of macrolides, the daily dose is 500-1000 mg divided into 3-4 doses 1-1.5 hours before meals. The drug is available in tablets or capsules of 0.1, 0.25 and 0.5 g. Possible side effects include nausea, vomiting, diarrhea, and liver dysfunction. The drug is contraindicated in case of individual intolerance, liver diseases with impaired liver function. It should be borne in mind that erythromycin is inactivated by dairy products and acidic drinks, and also increases blood levels and enhances the toxic effect of carbamazepine (tegretol, finlepsin) and theophylline.

Clindamycin (lincomycin group) is prescribed in a daily dose of 0.6 g, divided into 2 doses, available in capsules of 0.15 g and under the name Dalacin C - 0.15 and 0.3 g. The course of treatment is 7–10 days. Possible side effects include dyspepsia (nausea, vomiting, diarrhea), liver dysfunction. The drug is incompatible with erythromycin and B vitamins. Lincomycin is prescribed in a daily dose of 1500–2000 mg (2 tablets 3–4 times a day), available in capsules of 0.25 g. The duration of treatment and side effects are similar to clindamycin.

Josamycin or vilprafen in a daily dose of 1000 mg (1 tablet 2 times a day between meals) is used for 2–4 weeks, then 1 tablet. within 8 weeks. Possible side effects include dyspepsia (nausea, vomiting, diarrhea), liver dysfunction. The drug is incompatible with lincomycin and weakens the effect of hormonal contraceptives.

If antibiotics are intolerant, they resort to sulfonamide drugs, usually co-trimoxazole (Biseptol, Septrin, Groseptol, Cotripharm 480). The drug is prescribed 480-960 mg (1-2 tablets) 2 times a day during or after meals with an interval of 12 hours. During treatment, it is recommended to drink plenty of fluids, monitor the condition of the blood and urine, avoid solar and ultraviolet irradiation, and do not prescribe ascorbic acid.

It is logical to assume that local use of the above antibiotics may be much more effective and safer than internal use. However, research shows that topical application of erythromycin, clindamycin and tetracycline is effective only for mild acne, especially in combination with zinc, retinoids or benzoyl peroxide. External use of 1% erythromycin ointment (Ung. Erythromycini 1%) has a positive effect only in combination with other external and internal agents; gel with clindamycin Dalacin T (Pharmacia, USA) is more effective. Easy to use Eryderm (Abbott Labor, USA) – 2% solution of erythromycin. Levomycetinic, boric, and resorcinol alcohols are also used to dry and cauterize individual rashes. Combination preparations that are effective are Zinerit (Yamanouchi, Netherlands) - a solution of erythromycin and zinc acetate and Benzamycin, gel for external use, in 20 g tubes (Rhone-Poulenc Rorer, USA), containing 3% erythromycin and 5% benzoyl peroxide. All of the above drugs are prescribed 2 times a day. Like antibiotics prescribed orally, external medications tend to cause the development of antibiotic-resistant strains of microorganisms, so their repeated prescription is often ineffective. Resistance of Propionibacterium acnes strains (the main microorganism that multiplies in the sebaceous glands of patients) to commonly used antibiotics was found in 60% of patients. Increased resistance depends on the duration of therapy; resistance to erythromycin develops more often.

Other antiseptics and disinfectants. One of the successful modern approaches to treatment is the use of benzoyl peroxide, a lipophilic compound due to the presence of a benzoic acid residue in its composition. Benzoyl peroxide applied to the skin breaks down under the influence of air into peroxide and inactive benzoic acid, which remains on the surface of the skin. Active oxygen compounds damage the walls of bacteria, destroying them, and the content of fatty acids decreases, which prevents inflammation. At the same time, the same compounds also have a damaging effect on the horny scales, which is clinically expressed by peeling of the skin that accompanies the therapeutic effect. Benzoyl peroxide preparations have no effect on comedones, so they are not used if they predominate. Various companies offer this drug under the names Benzacne (Polfa, Poland), Desquam (Bristol-Myers, USA), Oxy 5 and Oxy 10 (SmithKline Beecham, UK), Baziron (Galderma, France). Benzoyl peroxide is available in the form of 2%, 5%, and 10% gel, 5% and 10% lotion. Treatment begins with applying a lower concentration of the drug to the face, then it is increased. A higher concentration is immediately applied to the back and chest. Benzoyl peroxide is applied to previously cleansed skin once a day. Side effects include an exacerbation reaction in the first days of use, dryness and flaking of the skin, discoloration of hair and linen when the drug comes into contact with them. Intolerance is common, so before starting treatment it is recommended to conduct a skin test - the drug is applied to a small area of skin on the flexor surface of the forearm for 48 hours. If there is no itching or redness, you can apply the drug to your face.

A combination of topical application of benzoyl peroxide in the morning and Retinoic ointment in the evening has a good effect, especially in the presence of comedones.

Azelaic acid inhibits the growth of microorganisms and reduces the content of free fatty acids on the skin surface. Skinoren cream or gel (“Schering”, Germany), containing 20% and 15% azelaic acid, respectively, is applied to the facial skin (both affected and rash-free areas) 2 times a day. When used, local skin irritation is possible. Skinoren is used in the complex treatment of acne; using it as an independent remedy usually does not bring success.

Zinc hyaluronate is part of the Curiosin gel (Gedeon Richter, Hungary), has a healing and antimicrobial effect. It can be used for a small number of rashes, since the effectiveness of the drug is low. The gel is applied to cleansed skin twice a day; a burning sensation and redness of the skin at the application sites are possible.

Povidone-iodine (Betadine) is used to lubricate pustules in a concentrated (10%) or diluted 1:1 solution with water 1-2 times a day. It is undesirable to use in fair-skinned and red-haired patients due to increased sensitivity to iodine. The diluted solution cannot be stored.

For a small number of comedones in the initial stage of the disease, salicylic alcohol 2–3% is effective. It is used 2 times a day, being careful not to apply to the entire affected area to avoid drying it out, but only to individual areas.

Sulfur is an anti-inflammatory agent; it is included as one of the components in most external agents (ointments and mash) traditionally used in the treatment of acne. However, in recent years, its comedogenic effect has been discovered, i.e. it can cause the formation of comedones.

Hormone therapy

Sex hormone therapy is only possible for women. Estrogens (ethinyl estradiol) and antiandrogens (cyproterone acetate, spironolactone) can be used for treatment. Estrogens reduce the secretion of the sebaceous glands, although not as significantly as retinoids. They can be used simultaneously with topical retinoic acid, antibiotics or benzoyl peroxide, which increases the therapeutic effect. To achieve a good result, estrogens must be given for a long time - at least 5 cycles. The first signs of improvement are noticeable only towards the end of the second or third cycle. Estrogen has many side effects - nausea, fluid retention in the body, swelling of the legs, weight gain, breast tenderness, skin pigmentation, increased risk of vascular thrombosis. Risk factors for side effects include smoking, alcohol consumption, obesity, and vascular diseases. Cyproterone acetate for the treatment of acne is used only in combination with estrogens. Of the combination drugs, Diane-35 and Janine (Schering, Germany) are used. The drug is prescribed 1 tablet per day, starting from the first day of the cycle, for 21 days with a break of 7 days. The antiandrogenic drug Cyproterone or Androcur (“Schering”, Germany) is prescribed 1 tablet (10 mg) per day, starting from the first day of the cycle for 15 days, a new course begins 4 weeks after the start of the first. Glucocorticosteroid drugs are prescribed orally or parenterally only for abscess and fulminant acne, which is extremely rare. External use of corticosteroid ointments is not indicated.

Drugs of other groups

Zincteral (Polfa, Poland) contains zinc sulfate, a deficiency of which is often found in patients with acne. Tablets of 0.124 g are prescribed 1-2 times a day during or immediately after meals for 1-2 months. There may be nausea in the first week of use. The drug enhances the effect of retinoids, but weakens the effect of tetracyclines. Homeopathic treatments include injections of Cutis compositum or Traumeel (Heel, Germany). Herbal medicine is still widely used as an auxiliary means - applications of badyagi pulp for resorption of individual large nodes, lotions with green tea, calamus rhizome, raspberry shoots. Infusions of plants with estrogenic effects (hop cones, sage leaves) are prescribed internally.

Skin care

Many patients, feeling the increased sebum secretion characteristic of acne, try to wash their face as often as possible using soap and a sponge. At the same time, the skin dries out, but sebum secretion does not become significantly lower, since fat is washed out only from the surface of the skin, without affecting the sebaceous glands themselves, located in its depths. In this regard, frequent washing of the skin (no more than once a day), or the use of sponges and washcloths is not recommended to avoid irritation and injury. Many people now use antimicrobial soap. But it changes the state of the microbial flora only on the surface of the skin and does not have a significant effect on the course of the disease. At the same time, antimicrobial additives contained in soap can cause irritation or allergic reactions. To cleanse the skin, it is better to use soft neutral soap for sensitive skin or special cosmetics intended for this purpose (cleansing with milk, then tonic), and to eliminate the shine of the face associated with the release of sebum to the surface, use cosmetic wipes or special mattifying wipes facilities. The widely held belief that decorative cosmetics should not be used for acne has also now been revised. Modern high-quality cosmetics that do not irritate the skin, mask existing defects well, do not significantly disturb sweating, and are not applied to the skin in a thick layer and can be used during the day. It should be removed at home. Some medications require the use of sunscreen. It is better to prefer gels and milk, and also be sure to quickly remove them from the skin indoors. Scrubs and peels may be recommended to smooth the surface of the skin and give it freshness, but are contraindicated during treatment with retinoids, benzoyl peroxide and tetracyclines.

The use of therapeutic masks with a drying effect and detergents is limited during treatment with retinoids and alcohol solutions. If there are pustules on the skin and severe inflammation, massage and cosmetic cleansing of the skin are contraindicated.

Diet

Both in the past and now, most dermatologists always recommend following a fairly strict diet. Our long-term observations have shown that the benefit of such restrictions is small, and only in a few patients there is a clear connection between eating certain foods (mainly chocolate) and increasing rashes. We usually recommend that patients adhere to a reasonable diet, without excesses, and include more fermented milk products and greens in their diet. However, 2-3 days of fasting during an exacerbation always gives a positive result. In general, when prescribing modern therapeutic agents, there is no need to follow any diet to achieve a good result. If the patient is to take part in a festive feast, it is better to stop taking oral medications for 2-3 days and prescribe enterosorbents (Polyphepan, Enterosgel, etc.).

Our recommendations for treating acne

Initial stage - a few small black dots appear on the nose and forehead (usually in children) - Salicylic alcohol, Retinoic ointment, Skinoren, medicinal cosmetics.
The same, but for significantly oily skin - Retinoic ointment, Salicylic alcohol.
Numerous black spots and individual inflammatory nodules and pustules - Retinoic ointment, Salicylic alcohol, on pustules - alcohols with antibiotics, Dalatsin T, Povidone-iodine.
The predominance of inflammation with a small number of comedones - Retinoids (Retinoic ointment, Retasol®), benzoyl peroxide (Benzacne, Desquam, Oxy 5 and Oxy 10, Baziron), external preparations with antibiotics (Dalacin T, Zinerit, Eriderm, Benzamycin).
The predominance of pustules in a common process (face, back, chest) - antibiotics, in some cases - retinoids internally (Roaccutane, Retinol palmitate), externally - benzoyl peroxide, disinfectants.
Individual large painful ulcers on the face - antibiotics, externally - antibiotic ointments and benzoyl peroxide.

Seborrhea and seborrheic dermatitis

In recent years, what was previously united by one term “seborrhea” has begun to be divided into 2 concepts – seborrhea of the head and seborrheic dermatitis (damage to smooth skin).

Seborrheic dermatitis

– chronic inflammatory skin disease. It affects 1-3% of adults (mostly men). Seborrheic dermatitis, along with acne, is a disorder of sebum secretion. Indeed, both diseases are often combined in the same person and affect the same areas of the skin - the so-called “seborrheic zones” - the face, chest (décolleté area) and the middle part of the back along the spine (interscapular region), where the largest sebaceous glands with wide ducts that secrete large amounts of sebum. Sebaceous glands of this type actively develop and increase in size during puberty. The composition of sebum also changes, it becomes more viscous, the components it contains contribute to increased keratinization, which corresponds to peeling visible to the eye. Smaller glands, but also secreting large amounts of sebum, are located on the scalp. Their purpose is to provide fat lubrication to the hair and make it invulnerable to external influences. These glands also become more active during puberty. In adolescents and adults, the mildest form of seborrheic dermatitis is characterized by flaking of the skin and its excess oiliness without inflammation - on the scalp it is dandruff, and on the face and chest - accumulations of fatty scales in the skin folds - near the wings of the nose, in the nasolabial fold, on the bridge of the nose , less often - on the chest and back. Fatty scales soaked in sebum serve as a good breeding ground for the development of lipophilic fungi Malassezia furfur or Pityrosporum ovale. In turn, the immune system reacts to them with the development of allergic dermatitis, the disease enters its second, more unpleasant phase, and is no longer limited to mild manifestations. Itching, burning, at first mild, then more intense redness of the skin, severe peeling, and hair loss appear. The manifestations of the disease are aggravated by the patients themselves - constant scratching, attempts to remove crusts, remove accumulations of scales from the hair, the use of “folk” remedies, and the most powerful ones, inevitably lead to increased redness, the appearance of scratches and wounds, the proliferation of other microbes, and the development of complications of the pustular process. It is usually in this condition that patients turn to a dermatologist, although everything could have been corrected much earlier.

For any manifestation of the disease, you should pay attention to your diet. Sometimes its correction is enough to prevent further development of the disease. Alcohol, sweets and starchy foods should be limited, regardless of the type of food. For itching and inflammation, smoked, salted, pickled foods, spicy seasonings, strong broths, instant coffee, citrus fruits, kiwi, pineapples and juices from them are also temporarily limited.

Treatment depends on the stage of development and clinical picture of the disease. If dandruff appears without inflammation, you can limit yourself to only external treatment; in more serious cases, internal treatment is also necessary. External treatment includes keratolytic, glucocorticosteroid, antiseptic, disinfectant and antifungal agents. Antifungal drugs are usually the starting point for treatment and can be used long-term without the risk of side effects. Various dosage forms are used - creams, gels, shampoos. Shampoos with antifungal substances - Nizoral, Keto-plus, Perhotal, Mycozoral, Sebozol contain 1-2% ketoconazole. Ti/Jel anti-dandruff shampoo contains 0.75% piroctone olamine and 2% salicylic acid. Creams and gels are applied 2 times a day, shampoos - 3 times a week. Various other medicinal substances that also have antifungal properties include zinc pyrithioneate, tar, sulfur, resorcinol and selenium disulfide. Medicines containing these compounds are available in the form of shampoos for the treatment of dandruff (Friderm-tar, Ti/Jel-Newtar, Friderm-zinc) and ointments for the treatment of smooth skin lesions (Skin-cap, birch tar, tar and sulfur-tar ointments ). Prescription forms are also used: Vidal milk, alcohol solutions with sulfur, boric acid, tar. After hair treatment, it is necessary to change combs, hair brushes, and hats.

For severe inflammation, anti-inflammatory, antiseptic and disinfectants are used. For weeping and severe swelling of the lesions, lotions with resorcinol 1% and herbal decoctions are used. The crusts are usually lubricated with alcohol solutions (salicylic, resorcinol, boric alcohols). Corticosteroids have a rapid anti-inflammatory effect - they are used on the head in the form of solutions - Elokom, Diprosalik (Schering-Plough USA), Lokoid (Janssen-Cilag Belgium), Belosalik (Belupo, Croatia), on seborrheic areas - in the form of ointments and creams - Elokom, Diprosalik, Belosalik, Hydrocortisone ointment. It should be noted that on the skin of the face, which is much thinner than in other areas, only non-fluorinated glucocorticosteroids can be used in the form of easily absorbed creams and emulsions (Advantan emulsion, Elokom cream, Lokoid cream) or weak (Prednisolone, Hydrocortisone) ointments. Drugs in this group are not suitable for long-term use due to the risk of undesirable effects - thinning of the skin, dilation of blood vessels, appearance or worsening of acne. When it is possible to relieve acute inflammation (usually in 3-5 days), and with residual peeling, they are replaced by drugs containing vitamin A - emulsion-based ointments Videstim®, Radevit® (FNPP “Retinoids”, Russia). It is known that vitamin A (retinol palmitate) reduces sebum secretion by reducing the size of the sebaceous glands and keratinization, and also has the properties of a local immunomodulator. Videstim® contains 0.5% retinol palmitate on an emulsion basis, Radevit® - 1% retinol palmitate, ergocalciferol and tocopherol acetate (vitamins A, D and E). The drugs are used for a long time, including for the purpose of preventing relapses. In recent years, the local immunomodulator pimecrolimus, supplied to Russia under the name Elidel, has also been used in treatment. Keratolytic agents are used for severe peeling and crusting. Apply sulfur-salicylic ointment 2-5% 1.5-2 hours before washing hair under a scarf, on the face - 1 hour before washing, 10% ointment with urea Carboderm (Ukraine). A particularly good effect is brought by combination drugs that combine the keratolytic properties of salicylic acid and anti-inflammatory glucocorticosteroids - Diprosalik, Belosalik. Internal remedies include vitamin A (retinol palmitate) in a daily dose of 100,000–200,000 IU (once at night for 2 months), B vitamins, in particular brewer’s yeast (Merz Germany and domestic companies), brewer’s yeast with the addition of zinc and selenium Nagipol, multivitamin-mineral complexes, preparations with selenium (Selevit, Triovit), zinc (Zincteral). To reduce sebum production in women, hormone therapy (Diane-35, Janine) and antiandrogens (Androcur) are used - see above. Despite successful therapy, the disease often recurs. A rational approach to diet and careful selection of skin and hair care products are necessary to maintain a favorable treatment result for as long as possible.

prof. IN AND. Albanova

Discussion

The study showed that Mycoplasma hominis and Ureaplasma spp. exhibit different sensitivity to the same groups of antibiotics. The exceptions are: for tetracyclines - doxycycline, for macrolides - josamycin and spiramycin, as well as some fluoroquinolones (Figures 1, 2), which have similar sensitivity.

The group of tetracyclines showed high activity against urogenital mycoplasmas, only the activity of tetracycline against Ureaplasma spp. turned out to be moderate, 2 times less than to M. hominis. Also to Ureaplasma spp. Almost all macrolides showed fairly high activity, except for spiramycin and midecamycin. The activity of midecamycin against Ureaplasma spp. was 4 times less in comparison with other macrolides, but 2 times higher than its activity against M. hominis. In general, the activity of most macrolides was greater against Ureaplasma spp. 32 times than to M. hominis. For M. hominis, the most active macrolide antibiotic was josamycin. Of the fluoroquinolones, sparfloxacin and moxifloxacin showed the greatest activity against M. hominis, and against Ureaplasma spp. sparfloxacin, levofloxacin and moxifloxacin. Levofloxacin was 2 times more active against Ureaplasma spp. than against M. hominis. The activity of ofloxacin was the same and was moderate against both Ureaplasma spp. and M. hominis. The activity of the remaining fluoroquinolones was approximately 4 times less than the active antibiotics against Ureaplasma spp., and 2 times (levofloxacin), or even 8 times (ciprofloxacin, pefloxacin and lomefloxacin) against M. hominis. However, in general, the activity of fluoroquinolones was 2 times higher in relation to M. hominis. Lincosamides and gentamicin showed moderate activity against M. hominis; only gentamicin showed moderate activity against Ureaplasma, but its activity was 2 times lower than against M. hominis.

Thus, we can say that the most active antibiotics against both M. hominis and Ureaplasma spp. is a group of tetracyclines and fluoroquinolones, and for Ureaplasma spp. also a group of macrolides. The most active antibiotics against M. hominis are tetracyclines, macrolides josamycin, and fluoroquinolones sparfloxacin, levofloxacin and moxifloxacin. Regarding Ureaplasma spp. The most active antibiotics are doxycycline from tetracyclines, all macrolides except midecamycin and spiramycin, and from fluoroquinolones sparfloxacin, levofloxacin and moxifloxacin. The most inactive than all other antibiotics studied against M. hominis and Ureaplasma spp. Spiramycin showed itself.

All data obtained as a result of the study formed the basis for the development of kits for determining antibiotic sensitivity to M. hominis and Ureaplasma spp., produced by the Federal Budgetary Institution of Scientific Research Institute of Epidemiology and Microbiology named after. Pasteur.

Picture 1

DOC - doxycycline, TET - tetracycline, ERI - erythromycin, KTM - clarithromycin, JM - josamycin, MDM - midecamycin, AZM - azithromycin, ROK - roxithromycin, SPM - spiramycin, OF - ofloxacin, CIP - ciprofloxacin, SPF - sparfloxacin, LVF - levofloxacin, MOK - moxifloxacin, PEF - pefloxacin, LOM - lomefloxacin, CL - clindamycin, LIN lincomycin, GEN - gentamicin.

Figure 2

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