Metrogyl gel for external application approx 10 mg/g aluminum tube 30 g

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Manufacturers: Unique Equipments

Active ingredients

• Metronidazole
• Chlorhexidine

Disease class

• Diseases of the pulp and periapical tissues
• Periapical abscess without cavity
• Acute gingivitis
• Chronic gingivitis
• Acute pericoronitis
• Chronic periodontitis
• Periodontal disease
• Periodontal disease, unspecified
• Alveolitis of the jaws
• Recurrent oral aphthae
• Lip diseases
• Other and unspecified lesions of the oral mucosa
• Presence of dentures

Clinical and pharmacological group

• Not indicated. See instructions

Pharmacological action

• Antibacterial
• Antiseptic (disinfectant)
• Bactericidal

Pharmacological group

• Other synthetic antibacterial agents in combinations
• Dental products in combinations

Compound

The Metrogyl solution contains the active ingredient metronidazole , as well as: sodium chloride, sodium hydrogen phosphate (anhydrous), citric acid, water.
Metrogyl tablets contain the active ingredient metronidazole , as well as: corn starch, magnesium stearate, colloidal silicon dioxide, hydrogenated castor oil, Opadry II dye, water.

Metrogyl gel includes metronidazole and additional components: propyl parahydroxybenzoate, methyl parahydroxybenzoate, disodium edetate, carbomer 940, sodium hydroxide, propylene glycol, water.

Metrogyl denta gel – price, composition and analogues

The cost is indicated for 2022. For Metrogyl denta gel the price will be from 280 rubles (per tube of 20 g). The minimum price in social pharmacies is about 250 rubles.

Metrogyl Denta gel: composition

The composition of the gel is written directly on the packaging -

→ Metrogyl Denta gel: instructions for use (official, PDF)

Composition analysis –

Thus, the drug contains 1% metronidazole and 0.05% chlorhexidine, which have an antimicrobial effect. But don't expect too much from this drug. The fact is that the concentrations of the active components are low enough to obtain a pronounced effect in patients with periodontitis (although such concentrations may be quite sufficient for the treatment of gingivitis). And this opinion is based not only on 10 years of clinical experience with the use of Metrogildent gel, obtained by the author of the article in the treatment of gum inflammation in his patients.

Scientific works will also help us with this (source), which shed light on the effectiveness of different types of antiseptics in the treatment of patients with gum inflammation, and allow us to compare them with each other. So, it turns out that the effectiveness of Chlorhexidine very, very much depends on its concentration. Let's see what this means.

Efficiency of antiseptics (from greatest to least) –

• 0.2% chlorhexidine,
• 0.1% hexetidine (hexoral),
• 0.05% chlorhexidine,
• 0.05% cetylpyridine,
• 0.01% miramistin.

In the scientific work, the link to which we provided above, the effectiveness of antiseptics was analyzed specifically in patients with chronic periodontitis. This form of gum inflammation is distinguished not only by its long-term chronic course, but also by the fact that periodontal pockets form around the teeth during periodontitis. So, if for gingivitis - 0.05-0.12% concentration of chlorhexidine may be quite sufficient to achieve clinical effectiveness, then for periodontitis - only 0.2% chlorhexidine is highly desirable.

Important: the fact is that in a large number of patients with periodontitis, not only bacterial but also fungal flora are sown from periodontal pockets. Clinical studies show that the addition of fungal flora makes pathogenic bacteria less sensitive to antimicrobial agents. This requires the use of higher concentrations of antiseptics and antibiotics, and these concentrations must be effective - including against fungal flora, and not just bacterial ones.

0.2% chlorhexidine meets all these requirements (and this applies not only to gels for gums, but also to antiseptic mouth rinses). Now let's see which patients with periodontitis most often develop an “association” of bacterial and fungal flora (24stoma.ru). For example, if you have long-term chronic inflammation of the gums, if you smoke, if you eat a lot of carbohydrates, if you have concomitant chronic tonsillitis, or have gastrointestinal diseases, or in the past there was at least 1 case of candidiasis (thrush) of any localization .

Conclusions : we recommend using Metrogyl denta gel only in the following situations. Firstly, for catarrhal gingivitis. Secondly, with the mildest initial form of periodontitis, i.e. when the depth of periodontal pockets does not exceed 3.5 mm - and only on the condition that nothing from the list above applies to you (i.e. you do not smoke, you do not have chronic tonsillitis, gastrointestinal diseases, and the list goes on). Moreover, if you are going to use Metrogyl denta, then we recommend doing this only as part of combination therapy, which we will discuss below.

Release form

Currently, Metrogyl solution is produced for intravenous administration, as well as tablets, vaginal gel and gel for external use.

• The solution for intravenous administration can be colorless or pale yellow, transparent, packaged in transparent ampoules of 20 ml (100 mg solution) and in polyethylene bottles of 100 ml (500 mg solution). The containers are placed in cardboard packs.
• Tablets 200 mg - pink, biconvex, film-coated, round, packaged in blisters of 10 pcs., in cardboard packs of 2 blisters.
• Tablets 400 mg - orange, biconvex, film-coated, round, packaged in blisters of 10 pcs., in cardboard packs of 2 blisters.
• Metrogyl vaginal gel is homogeneous, colorless or has a yellow tint, contained in tubes of 30 g.

pharmachologic effect

The broad-spectrum medicine contains metronidazole , a 5-nitroimidazole derivative.

The drug has antimicrobial and antiprotozoal effects. The mechanism of action is based on the reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The 5-nitro group of metronidazole interacts with the DNA of microbial cells, inhibiting the synthesis of their nucleic acids. As a result, the bacteria die.

Metrogyl demonstrates activity against Gardnerella vaginalis, Trichomonas vaginalis, Giardiai ntestinalis, Entamoeba histolytica, Lamblia spp. The drug is also active against obligate anaerobes and a number of gram-positive microorganisms.

If metronidazole is combined with Amoxicillin , activity against Helicobacter pylori is manifested.

Facultative anaerobes and aerobic microorganisms do not show sensitivity to metronidazole, however, in the presence of mixed flora, there is a synergistic effect of metronidazole with antibiotics that are effective against aerobes.

It provokes disulfiram-like reactions, under its influence the sensitivity of tumors to radiation increases, and reparative processes are stimulated.

When applied externally, an anti-acne effect is observed, the mechanism of which is not fully known. Metrogyl ointment appears to demonstrate antioxidant activity. Under the influence of this drug, the production of active oxygen, hydrogen peroxide, and hydroxyl radicals by neutrophils is reduced, that is, potential oxidants that contribute to tissue damage in the place where the inflammatory process develops.

The external form of the drug is active against telangiectasia in rosacea .

Metrogyl gel for external application approx 10 mg/g aluminum tube 30 g

Registration Certificate Holder

UNIQUE PHARMACEUTICAL Laboratories (India)

Dosage form

Medicine - Metrogyl® (Metrogyl®)

Description

Gel for external use

homogeneous, colorless to yellow.

1 g

metronidazole 10 mg

Excipients

: methyl parahydroxybenzoate, propyl parahydroxybenzoate, carbomer 940, disodium edetate, sodium hydroxide, propylene glycol, purified water.

30 g - aluminum tubes (1) - cardboard packs.

Indications

• rosacea (including post-steroid acne);
• acne vulgaris;
• oily seborrhea, seborrheic dermatitis;
• trophic ulcers of the lower extremities (against the background of varicose veins, diabetes mellitus);
• poorly healing wounds;
• bedsores;
• hemorrhoids, anal fissures.

Contraindications for use

• hypersensitivity to the components of the drug.

pharmachologic effect

Metronidazole is a synthetic broad-spectrum antimicrobial and antiprotozoal agent from the group of imidazoles. Active against anaerobes

(Bacteroides spp., Fusobacterium spp., Mobiluncus spp., Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Eubacterium spp., Bacteroides fragilis, Prevotella spp.) and
protozoa
(Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica).
When applied topically, it has an anti-acne effect, the mechanism of which is precisely unknown (not related to the effect on the Demodex folliculorum mite, found in hair follicles and the secretion of the sebaceous glands, and any effect on the production of this secretion).
Metronidazole for external use may have antioxidant activity. It has been found that it significantly reduces the production of active oxygen, hydroxyl radicals and hydrogen peroxide by neutrophils, which are potential oxidants that can cause tissue damage at the site of inflammation. Metronidazole for external use is not effective against telangiectasias noted with rosacea.

Drug interactions

When the gel is applied topically, interaction with other drugs is negligible, but caution should be exercised when administered simultaneously with warfarin and other indirect anticoagulants (increases prothrombin time).

Dosage regimen

For external use. The gel is applied to previously cleansed affected areas of the skin in a thin layer 2 times a day, morning and evening, for 3-9 weeks.

The duration of treatment is 3-4 months, the therapeutic effect is usually observed after 3 weeks of treatment.

Overdose

There were no cases of drug overdose in recommended doses when using the drug externally.

Side effect

When the gel is applied topically, the concentration of metronidazole in the blood is very low, so the risk of systemic side effects is low.

Rarely

Allergic reactions may occur (urticaria, skin rash); hyperemia, peeling, slight dryness and burning of the skin, lacrimation (if the gel is applied close to the eyes).

special instructions

Avoid contact with eyes. If the gel gets into your eyes, rinse them immediately with plenty of water.

Storage conditions

Store at a temperature not exceeding 30°C, out of the reach of children. Do not freeze.

Best before date

Shelf life: 3 years. Do not use after the expiration date stated on the packaging.

Use during pregnancy and breastfeeding

Restrictions during pregnancy - With caution. Restrictions when breastfeeding - With caution.

Carefully -

I trimester of pregnancy, lactation period.

Terms of sale

The drug is approved for use as a means of OTC.

Pharmacokinetics and pharmacodynamics

After a patient has been administered Metrogyl intravenously, approximately 30-60% of the substance is metabolized through hydroxylation, oxidation and glucuronidation. As a result, a metabolite, 2-oxymetronidazole, is formed, which also produces an antiprotozoal and antimicrobial effect. The half-life is 8 hours (subject to normal liver function), up to 18 hours (if the liver is damaged by alcohol).

Approximately 60-80% of the administered dose is excreted through the kidneys, another 6-15% is excreted through the intestines. Both metronidazole and its metabolites are eliminated from the blood by hemodialysis .

If the antibiotic is taken orally, it is quickly absorbed, and its maximum concentration in the blood is observed after 2 hours. The product has a high ability to penetrate tissues and body fluids. 10-20% bound to plasma proteins. About 60-80% is excreted through the kidneys, while approximately 20% is excreted unchanged. Half-life is 8 hours.

When the product is used externally, a minimal amount is absorbed, so only traces of the active component are detected in the blood. It should be taken into account that the absorbed active substance passes the blood-brain and placental barriers.

Indications for use

The instructions define the following indications for the use of Metrogyl intravenously:

• protozoal infections: ( trichomoniasis , extraintestinal and intestinal amebiasis , balantidiasis , giardiasis , cutaneous leishmaniasis , giardiasis , vaginitis and urethritis );
• infectious diseases caused by Bacteroides spp.: infections of the abdominal cavity, pelvic organs, skin, soft tissues;
• infections caused by Bacteroides spp.: infections of the nervous system, joints, bones, including brain abscess , meningitis , endocarditis , empyema , lung abscess , pneumonia ;
• infectious diseases caused by Bacteroides spp., including Clostridium spp., B. Fragilis: sepsis ;
• pseudomembranous colitis as a result of treatment with antibiotics;
• alcoholism;
• gastritis or ulcer as a result of the action of Helicobacter pylori;
• prevention of complications after surgery.

It is advisable to prescribe tablets in the following cases:

• to prevent the development of postoperative complications (in particular gynecological);
• for protozoal infections ( giardiasis , trichomoniasis , amoebic dysentery , amebiasis etc.);
• anaerobic infections (those that were provoked by Bac.fragilis, as well as clostridia , fusobacteria , anaerobic cocci , eubacteria );
• period after operations;
• infectious diseases of the respiratory tract;
• gas gangrene ;
• septicemia;
• osteomyelitis;
• meningitis , brain abscess ;
• tetanus.

Metrogyl cream is prescribed for the following diseases and conditions:

• acne vulgar;
• rosacea;
• seborrheic dermatitis , oily seborrhea;
• trophic ulcers that appear on the lower extremities as a result of varicose veins , diabetes mellitus ;
• bedsores;
• wounds that heal poorly;
• anal fissures , hemorrhoids .

Metrogyl vaginal gel is indicated for the treatment of vaginitis , which is caused by metronidazole-sensitive microflora, as well as for the treatment of urogenital trichomoniasis .

Contraindications

IV Metrogyl is contraindicated for use in the following conditions and diseases:

• organic lesions of the nervous system ( epilepsy , etc.);
• blood diseases;
• liver failure (large doses cannot be taken);
• blood diseases;
• lactation and pregnancy (first trimester);
• nitroimidazole derivatives .

Intravenous injections are given with caution to people suffering from renal failure.

Metrogyl tablets should not be taken in the following cases:

• with organic lesions of the nervous system, in particular epilepsy ;
• for blood diseases;
• for liver failure (large doses of tablets);
• under the age of 12;
• during pregnancy (first trimester);
• high sensitivity to the active substance, to other nitroimidazole .

Prescribed with caution to people with liver and kidney diseases.

Vaginal gel is not prescribed for the following diseases and conditions:

• impaired coordination of movements;
• leukopenia (also in history);
• lesions of the nervous system of an organic nature, including epilepsy ;
• pregnancy (first trimester);
• liver failure;
• high sensitivity, also sensitivity to nitroimidazole derivatives.

Metrogyl Denta during pregnancy and lactation -

In the previous version of the instructions for Metrogyl-Dent gel, it was contraindicated for use, but only during the 1st trimester of pregnancy. In the current version of the instructions, it is only “not recommended for use,” but throughout pregnancy (pregnancy is not a complete contraindication for the use of the drug). Thus, Metrogyl denta can still be used during pregnancy, but only in consultation with your doctor.

Regarding breastfeeding, it is best to temporarily stop breastfeeding while using this drug. An interesting point is that if you compare this information with the recommendations of the FDA (U.S. Drug Administration), then according to their recommendations, metronidazole can be taken by pregnant women and is also quite safe when breastfeeding.

Alternatives during pregnancy and breastfeeding - an alternative can be the drug Cholisal, which, in accordance with the manufacturer’s instructions, can be taken throughout pregnancy and the breastfeeding period, but also “with caution.” The term “with caution” means that you should not take the drug unsupervised - it should be prescribed by your dentist, and you should also inform your obstetrician-gynecologist about its prescription.

Contraindications to the use of Metrogyl Denta gel:

• children under 18 years of age,
• allergic reactions to the components of the gel,
• blood diseases,
• diseases of the nervous system.

Side effects

When using the drug intravenously and orally, the following side effects may develop:

• Gastrointestinal tract: loss of appetite, diarrhea , nausea , intestinal colic, vomiting , constipation , dryness or metallic taste in the mouth, glossitis , pancreatitis , stomatitis ;
• nervous system: impaired coordination, dizziness , impaired consciousness, ataxia , severe excitability, irritability, insomnia , weakness, headache , hallucinations , convulsions ;
• allergies: rash, hyperemia , urticaria , fever , nasal congestion, arthralgia ;
• urinary system : cystitis , dysuria , urinary incontinence , polyuria , candidiasis , change in urine color to red-brown;
• local manifestations: thrombophlebitis , development of pain, swelling, redness at the site of drug administration;
• other manifestations: leukopenia , neutropenia .

When using Metrogyl gel for topical use, a small amount of the active component is absorbed into the blood, so systemic side effects are unlikely. Rarely, the development of allergic manifestations, lacrimation, dryness and burning of the skin is possible.

Gel Metrogyl Denta

Instructions for medical use of the drug

Description of pharmacological action

It has an antibacterial effect against anaerobic bacteria that cause periodontal diseases: Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium fusiformis, Wolinella recta, Eikenella corrodens, Borrelia vincenti, Bacteroides melaninogenicus, Selenomonas spp.

Indications for use

Infectious and inflammatory diseases of periodontal and oral mucosa: - acute and chronic gingivitis; — acute ulcerative-necrotizing gingivitis of Vincent; — acute and chronic periodontitis; — juvenile periodontitis; - periodontal disease complicated by gingivitis; - aphthous stomatitis; - cheilitis; - inflammation of the oral mucosa when wearing dentures; — post-extraction alveolitis (inflammation of the socket after tooth extraction); - periodontitis, periodontal abscess (as part of combination therapy).

Release form

gel for use in dentistry; plastic tube of 5,10,20,30 or 50 g, cardboard pack 1; gel for use in dentistry; aluminum tube of 5,10,20,30 or 50 g, cardboard pack 1;

Pharmacodynamics

The effectiveness of the drug is due to the presence of two antibacterial components in its composition: a) metronidazole has an antibacterial effect against anaerobic bacteria that cause periodontal diseases: Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium fusiformis, Wolinella recta, Eikenella corrodens, Borrelia vincenti, Bacteroides melaninogenicus, Selenomonas spp. b) chlorhexidine is a broad-spectrum antiseptic that has a bactericidal effect against vegetative forms of gram-negative and gram-positive microorganisms, as well as yeast, dermatophytes and lipophilic viruses.

Pharmacokinetics

When applied topically, Metrogyl Denta gel is practically not absorbed.

Use during pregnancy

It is not recommended to prescribe the drug to pregnant women in the first trimester of pregnancy. During lactation, the issue of stopping breastfeeding should be decided.

Contraindications for use

individual intolerance to metronidazole, chlorhexidine, as well as nitroimidazole derivatives and any components included in the drug; children under 6 years of age.

Side effects

When using Metrogyl Denta gel topically, the risk of developing systemic side effects is low, but sometimes the following may occur: headache, allergic reactions (skin rash, itching, urticaria).

Directions for use and doses

Topically, for dental use only. For adults and children over 6 years old with gum inflammation (gingivitis), Metrogyl Denta is applied to the gum area 2 times a day; it is not recommended to wash off the gel. The duration of treatment is on average 7–10 days. After applying the gel, you should refrain from drinking and eating for 30 minutes. In case of periodontitis, after removing dental plaque, periodontal pockets are treated with Metrogyl Denta gel and the gel is applied to the gum area. Exposure time - 30 minutes. The number of procedures depends on the severity of the disease. In the future, the patient can apply the gel independently: Metrogyl Denta is applied to the gum area 2 times a day for 7–10 days. For aphthous stomatitis, Metrogyl Denta is applied to the affected area of ​​the oral mucosa 2 times a day for 7–10 days. To prevent exacerbations of chronic gingivitis and periodontitis, Metrogyl Denta gel is applied to the gum area 2 times a day for 7–10 days. Preventive courses of treatment are carried out 2–3 times a year. To prevent post-extraction alveolitis after tooth extraction, the hole is treated with Metrogyl Denta® gel, then the gel is applied on an outpatient basis 2-3 times a day for 7-10 days.

Overdose

There were no cases of drug overdose with topical use.

Interactions with other drugs

When applied topically in recommended doses, no systemic interaction of Metrogyl Denta gel with other drugs was detected.

Special instructions for use

The use of Metrogyl Denta gel does not replace hygienic brushing of teeth, therefore, during the course of treatment with the drug, teeth brushing should be continued.

Storage conditions

List B.: At a temperature not exceeding 25 °C.

Best before date

36 months

ATX classification:

A Digestive tract and metabolism

A01 Dental preparations

A01A Dental preparations

A01AB Antimicrobials for topical use in diseases of the oral cavity

A01AB11 Other antimicrobials

Instructions for use of Metrogyl (Method and dosage)

Metrogyl solution, instructions for use

A Metrogil dropper is indicated in cases of severe infectious diseases, as well as in cases where the patient is unable to take the medicine orally.

Adolescents over 12 years of age and children receive the drug intravenously (duration of administration is about 40 minutes), the initial dose is 0.5-1 g. Then 500 mg should be administered every 8 hours (rate 5 ml/min.). If a person tolerates the injection normally, then after 2-3 infusions the drug can be administered in a stream. The injections must be taken for 7 days.

If necessary, a longer administration of the medicine is practiced. The permissible dose per day is 4 g. If indicated, maintenance doses can be used - 400 mg three times a day.

A similar regimen of use is practiced for children under 12 years of age, a single dose is 7.5 mg/kg.

To treat purulent-septic diseases, one course of therapy is sufficient.

For prevention, adolescents over 12 years of age and adults are given 0.5-1 g of medication intravenously before surgery, and 1.5 g per day on the day after surgery, that is, 500 mg every 8 hours. After 1-2 days, the patient can be transferred to maintenance oral medication.

If liver and kidney function are impaired, you should not take more than 1 g of medication per day; the dose should be divided into 2 doses.

Metrogyl tablets, instructions for use

You can take the tablets both during and after meals; they do not need to be chewed.

The dose for adults and adolescents over 15 years of age is 200-400 mg two to three times a day. per day

Both the dosage and duration of the course depend on the infection.

For trichomoniasis, you need to drink 200 mg 3 times for 7 days, while women take additional vaginal products with metronidazole. You can increase the dose or repeat the course of therapy if necessary.

For amebiasis , adults receive 400 mg 3 times a day. per day, children - 30-40 mg per 1 kg/day, the dose is divided into three doses. You need to take Metrogyl for up to 10 days.

For amoebic liver abscess, adults receive 400 mg or 800 mg three times a day, the drug is combined with tetracyclines. Children - 30-35 mg per 1 kg/day, the dose is divided into three doses. Therapy lasts up to 10 days.

For anaerobic bacterial infections, adults receive 200-400 mg 2-3 times. per day, children should receive 7 mg per 1 kg of weight every 8 hours. Therapy lasts up to 10 days.

For the purpose of prevention before operations, you need to take 1000 mg once, then 200 mg three times a day.

If Metrogyl is combined with amoxicillin, the dose of metronidazole per day should be 1.5 g, divided into three doses.

Vaginal gel Metrogyl, instructions for use

The ointment is applied intravaginally, once in a dose of 2 g or 500 mg twice a day, 10 days. During this time, sexual activity is not allowed.

Metrogyl gel for thrush is used as prescribed by a doctor.

The gel is applied externally to cleansed skin twice a day, treatment lasts from 3 to 9 weeks, it is possible to use the product for a longer time - up to 4 months. An occlusive dressing can be applied if necessary.

Metrogyl for acne

Often those who use Metrogyl gel on their face give positive reviews for acne. Despite the fact that the official instructions do not provide detailed information about the use of this medicine for the face, Metrogyl gel for acne is still used very often, since metronidazole has a bactericidal and bacteriostatic effect. Accordingly, it helps to get rid of dermatological problems. If the patient has single pimples, it is enough to apply the ointment several times.

In the case of acne, treatment may take longer. However, after the first use, the severity of negative symptoms decreases. Metrogyl is used as the main remedy for the treatment of acne, and in combination with other drugs. Apply the gel twice a day to areas affected by acne.

Metrogyl and Differin

Differin , which is a synthetic retinoid, contains the active component adapalene. This drug has a beneficial effect on the skin; when used with Metrogyl, users note a more pronounced effect.

Treatment of catarrhal gingivitis

Treatment tactics depend on the stage of pregnancy. A course of therapy can only be prescribed by a doctor!

Removal of dental plaque.

Ultrasonic teeth cleaning is contraindicated for pregnant women, so hand tools are used to remove plaque. After the procedure, the teeth are polished.

Antimicrobial therapy.

The course may include rinsing with antiseptic mouth rinses, as well as the use of special medicinal gels and toothpastes.

Maintaining oral hygiene.

It is necessary to brush your teeth twice a day - in the morning and before bed, and after each meal. It is also necessary to use floss. Regular use of a mouthwash such as LISTERINE® is also important.

Up to contents

Interaction

The dropper with Metrogyl should not contain other medications - it is not recommended to mix the product with other drugs.

Metronidazole activates the effect of indirect anticoagulants, resulting in an increase in the time of prothrombin .

Causes ethanol . When used simultaneously with Disulfiram, a variety of neurological symptoms may develop. It is important to keep the interval between taking these medications at least 2 weeks.

When taking Cimetidine , the metabolism of metronidazole is suppressed, so the concentration of the latter may increase, which leads to the development of side effects.

With the simultaneous use of Phenobarbital , phenytoin , that is, drugs that stimulate microsomal oxidation enzymes in the liver, it is possible to accelerate the elimination of metronidazole. As a result, its plasma concentration decreases.

If metronidazole is taken simultaneously with lithium preparations, the concentration of the latter in plasma may increase. In this case, signs of intoxication of the body may appear.

You should not combine Metrogyl with non-depolarizing muscle relaxants .

The antimicrobial effect of metronidazole is enhanced by sulfonamides .

When the gel is applied topically, there is no significant interaction with other drugs, but it should be used with caution with Warfarin and other indirect anticoagulants, since an increase in prothrombin time is possible.

Causes

The development of gingivitis in pregnant women may be associated with changes in hormonal levels, which are characterized by:

However, hormonal changes usually only predispose to the occurrence of gingivitis, and its actual causes are as follows:

• accumulation of soft plaque due to poor oral hygiene;
• exacerbation of sluggish chronic gingivitis during pregnancy.

Up to contents

special instructions

It is not recommended to combine Metrogyl with amoxicillin in patients under 18 years of age.

Long-term therapy requires constant monitoring of the blood picture.

If the patient develops leukopenia , continuation of therapy depends on whether there is a risk of an infectious process.

Therapy should be discontinued if the patient develops dizziness , ataxia and other symptoms indicating a deterioration in neurological status.

Under the influence of the drug, immobilization of treponema may occur, which leads to a false-positive Nelson test.

During treatment, the urine turns dark.

During the treatment of trichomonas vaginitis and urethritis, you should abstain from sexual intercourse. It is important that both sexual partners undergo therapy at the same time. During menstruation, treatment is not stopped.

Do not allow the gel to get into your eyes. If this happens, you need to rinse your eyes with warm water.

The Metrogyl dropper in gynecology is used only as prescribed by the attending physician.

In cosmetology, Metrogyl gel for the face is used to treat acne and other skin lesions. You can use it on your face only on the recommendation of a specialist.

Analogs

Level 4 ATC code matches:
Oflokain

Furasol

Chlorophyllipt

Oflomelid

Rozamet

Currently, numerous analogues of Metrogyl gel, tablets and solution are produced. These are the drugs Deflamon , Batsimex , Klion , Metrovagin , Metrolacare , Metron , Orvagil , Trichobrol , Trichopol , Siptrogil , Rosex , etc. Suppositories with the active substance metronidazole .

Reviews about Metrogil

In most reviews about the drug, users write that all forms of the drug are quite effective. Women who have used Metrogyl vaginal gel leave reviews that the medicine is convenient to use and at the same time it helps to quickly and quite effectively cope with the treatment of infectious diseases. Many women write that vaginal gel helped cure thrush .

There are also often opinions that Metrogyl ointment is an excellent remedy for treating acne . Reading reviews about Metrogyl for acne, we can conclude that this medicine significantly improves the situation after a course of use. Patients consider severe dryness of the skin when using the cream to be a negative point. However, it is often used to combat acne; women also use external remedy Metrogyl under the supervision of a doctor during pregnancy.

Metrogil price, where to buy

The price of Metrogil in tablets is about 80 rubles per pack; suppositories with metronidazole can be bought at a price of 100 rubles.

You can buy Metrogyl facial gel for 160 – 180 rubles.

The price of ampoules depends on the volume; an IV solution in 5 ml ampoules costs 30 rubles. for 1 ampoule. The cost of 100 ml ampoules (for a dropper) is about 80 rubles.

Vaginal gel Metrogyl, price

You can buy vaginal gel for an average of 170 rubles (30 g ointment). The price of the gel in Ukraine (Kharkov, Kyiv, etc.) is 80 – 90 hryvnia. You can find out how much the gel costs at a specific pharmacy.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Metrogyl Plus vaginal gel (tube) 50g + applicator 10 pcs. Unique Pharmaceutical Laboratories
  329 rub. order
• Metrogyl gel for external use. approx. 1% 30gUnique Pharmaceutical Lab.

  RUB 241 order

• Metrogyl Denta dental gel for gums 20g 1pcUnique Pharmaceutical Lab.

  RUB 313 order

• Metrogyl Plus vaginal gel tube 50 g + applicator 1 pc. Unique Pharmaceutical Laboratories

  RUB 267 order

• Metrogyl A gel for external application. approx. for acne 0.1% +1% 20gUnique Pharmaceutical Laboratories

  RUR 431 order

Pharmacy Dialogue

• Metrogil vag. gel (tube 30g with applique)Unique Farm Lab

  RUB 173 order

• Metrogyl plus vag.gel (tube 50g + application No. 1)Unique Farm Lab

  RUB 252 order

• Metrogyl Denta (gel for gums tube 20g)Unique Farm Lab

  RUB 317 order

• Metrogyl gel (tube 30g)Unique Farm Lab

  RUB 222 order

• Metrogyl Denta gel for gums 20gUnique Farm Lab

  RUB 298 order

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Pharmacy24

• Metrogyl Denta 20 g gel Unik Pharmaceutical Laboratories, India
  55 UAH order
• Metrogyl 30 g gel Unik Pharmaceutical Laboratories, India

  78 UAH order

• Metrogyl 30 g gel Unik Pharmaceutical Laboratories, India

  85 UAH order

• Metrogyl 5 mg/ml 100 ml solution for infusion

  20 UAH order

PaniPharmacy

• Metrogyl denta gel Metrogyl denta gel 20g India, Unique

  61 UAH order

• Metrogyl gel Metrogyl gel 30g India, Unique

  92 UAH order

• Metrogyl gel Metrogyl vag. gel 30g with appl. India, Unique

  103 UAH order

• Metrogyl infusion Metrogyl solution inf. 100ml India, Unique

  24 UAH order

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Note!

The description of the drug Metrogyl gel tube 30g on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.