Treatment of children with acute pharyngitis with local anti-inflammatory drugs

Composition and release form

Miramistin is a 0.01% solution of eye drops, colorless, transparent, and may foam when shaken. Each milliliter contains:

• Active ingredient: benzyldimethyl-myristoylamino-propylammonium chloride monohydrate – 0.1 mg
• Additional components: purified water.

Packaging: white polyethylene bottles of 50, 100, 200 ml in cardboard packs.

The bottle can be equipped with an applicator with a screw cap, as well as a sprayer or a spray pump to create an aerosol (however, this form is practically not used in ophthalmology). What cardboard packaging might look like is shown in the photo on the page. In some cases, the design may differ from what is shown.

Composition of Miramistin for children's throats

The colorless foaming preparation in the form of a solution is based on the substance benzyldimethyl[3-(myristoylamino)propyl]ammonium chloride monohydrate from the group of disinfection antiseptics in an amount of 0.1 g. Additionally, highly purified water is used - up to 1000 ml.

A liquid medicine with a concentration of 0.01% of the main substance for topical use is produced by the manufacturer in the form:

• polyethylene bottles with a volume of 0.05, 0.1, 0.15 and 0.5 l for household use;
• glass bottles of 1 and 10 liters for professional use;
• 5 liter canisters intended for use in inpatient departments of medical institutions.

In pediatric otolaryngology, it is used as one of the areas in the treatment of pathological conditions and elimination of foci of inflammation in parts of the throat:

• the walls of the pharynx lined with glandular epithelium;
• accumulations of lymphoid nodules in the palate;
• pharyngeal tonsil.

The peculiarity of the action of the drug, revealed when taken together with other active substances, is to enhance their effectiveness in the fight against fungi and pathogens.

Pharmacological properties

Miramistin solution is an antiseptic drug with a bactericidal effect. Shows activity against gram-positive bacteria and viruses, including herpes viruses and human immunodeficiency viruses. It also has an antifungal effect. It is also effective against antibiotic-resistant bacteria and sexually transmitted pathogens.

Miramistin prevents infection of burns and wounds. Stimulates regeneration processes. Activates local protective reactions, due to the improvement of the absorption and digestive functions of phagocytes, potentiates the activity of the monocyte-macrophage system. It has hyperosmolar activity, which allows it to stop wound and perifocal inflammation, absorbs purulent exudates, and promotes the formation of a dry scab. The use of the drug does not damage granulations, does not suppress marginal epithelization, and does not affect viable skin cells. The drug stimulates the resorption of dark spots on the cornea, prevents the formation of cataracts, prevents perforation and the development of ulcerative-necrotic and purulent complications, including when used in the treatment of burns and eye injuries.

When applied topically, it does not cause irritation or allergic reactions. The medicine, including in the form of eye drops, does not have embryotoxicity, carcinogenic or mutagenic properties: the antiseptic is harmless to the body when applied topically. It is not absorbed through the skin and mucous membranes, and practically does not enter the systemic circulation.

Reviews for Miramistin

An excellent remedy for preventing sexually transmitted infections. Once my partner and I had a condom break. At first I panicked, because we had known each other not so long ago, and then I started looking on the Internet for what to do in this case... I found an article about Miramistin... It turned out to be in a nearby pharmacy and we used it.

Elena

I have chronic tonsillitis, my throat often hurts and Miramistin helps me well. The spray form is very convenient, so treating the throat with it is very easy. I spray it for a few days and everything goes away. Excellent tool!

Tatiana

I work in the garden and garage and sometimes I hurt my hand. I wash the wound with miramistin and apply a plaster. After several treatments everything heals quickly. The drug has a good antiseptic effect.

Sergey

Indications for use

• Conjunctivitis, including chronic.
• Blepharoconjunctivitis.
• Traumatic keratitis.
• Eye burns, corneal erosions.
• Ophthalmochlamydia.
• Keratouveitis and corneal ulcers.
• Purulent-inflammatory processes in the anterior segment of the eye.
• Preoperative preparation, conditions after eye surgery.

In ophthalmology, Miramistin is used in complex treatment of the consequences of thermal and chemical burns and injuries to the visual organs in adults and children over 3 years old, as well as for infectious and inflammatory diseases. The drug can be used in combination with other antiseptic and antibacterial agents as prescribed by a doctor.

Miramistin for throat treatment for children 2 years old

The use of Miramistin for the throat of children aged 2-2.5 years still excludes gargling, so the drug solution is used for inhalation using a nebulizer.

To prepare an inhalation solution, 5 ml of 0.1% medication is mixed with 10 ml of water and the vapor of the drug is allowed to inhale for 5-7 minutes. The procedure is considered to be correctly performed when the child inhales through the mouth and exhales through the nose.

Therapeutic manipulation is carried out twice a day until the pathological symptoms are eliminated, but not longer than 7 days.

Directions for use and doses

The standard dosage of Miramistin solution is 2 drops conjunctivally 4-5 times daily. The frequency and volume of use in a particular case may differ from the standard ones, since in each situation the format of use is determined by the attending physician. The course of treatment can last from 3 to 10 days, which is determined by the doctor and depends on the severity of the pathology. It is not recommended to use a package form with a spray or a spray pump and spray the medicine into the affected area: this makes it difficult to calculate the dosage. It is recommended to use a package with an applicator to adjust the dose more accurately.

In order to prevent surgical infections, Miramistin solution is prescribed two days before surgery, 1-2 drops three times a day, and another 10-15 days in the postoperative period (at the same dosage) in combination with other drugs that suppress pathological activity. In some cases, the drug is dripped in a hospital setting during pre- and postoperative hospitalization.

Treatment of children with acute pharyngitis with local anti-inflammatory drugs

What are the symptoms of acute pharyngitis? What do treatment measures include? What are the features of treating infants?

Acute pharyngitis is an acute inflammation of the pharyngeal mucosa - a common manifestation of acute respiratory diseases. Typically viral in origin, it may also be associated with group A β-hemolytic streptococcus, Mycoplasma pneumoniae, or other pathogens.

As a rule, with pharyngitis, children complain of pain, discomfort in the throat (burning, soreness, itching), coughing, and sometimes itching and pain in the ears. Infants cannot complain of being unwell, but attentive parents pay attention to restless behavior, sleep disturbances, and worsening appetite. Pharyngitis can be combined with other manifestations of acute respiratory infections, such as runny nose, cough, fever, conjunctivitis.

The diagnosis of pharyngitis is made based on examination of the pharynx: there is hyperemia, swelling and infiltration of the mucous membrane of the posterior wall of the pharynx, velopharyngeal arches, and sometimes the soft palate. With lateral pharyngitis, hyperemia and swelling of the lateral ridges of the pharynx are determined. It is difficult to distinguish viral pharyngitis from bacterial pharyngitis based only on physical examination data. In both cases, during pharyngoscopy, the mucous membrane of the pharynx may be slightly hyperemic or severely inflamed and covered with a film or purulent exudate. Fever, cervical lymphadenopathy and leukocytosis are observed with both viral and bacterial pharyngitis, but perhaps they are more pronounced with the latter.

Therapeutic measures for pharyngitis include the following manipulations.

• Gargling with antiseptic, herbal solutions (for example, a solution of chlorophyllipt, rotokan, sea salt, eucalyptus, etc.) 3 - 4 times a day after meals.
• Irrigation of the pharynx with antiseptic or antibiotic-containing aerosols (such as Hexoral, Ingalipt, Cameton, Stopangin, Yox, Bioparox, Tantum Verde, etc.) 2-3 doses 2-4 times a day.
• Resorption of tablets or lozenges with an antibacterial, analgesic, emollient substance (faringosept, falimint, strepsils, laripront, etc.).
• For bacterial pharyngitis, systemic antibiotics are necessary.

Infants and young children cannot gargle or swallow tablets, so they are only prescribed to drink plenty of fluids and irrigate the throat with an antiseptic. It should be noted that children under two years of age should use all aerosols with caution due to the possibility of developing a spasm of the glottis.

The purpose of this study was to evaluate the effectiveness of a complex of local conservative measures administered to children with acute pharyngitis.

The study covered the period from October to December 2002. We observed 32 children (15 boys and 17 girls) aged 5 to 15 years (average age 9 years) with a diagnosis of acute pharyngitis. In most cases, pharyngitis was a manifestation of an acute respiratory viral infection. Children with ARVI complicated by other pathologies of the ENT organs or upper respiratory tract (sinusitis, acute catarrhal otitis media, tracheobronchitis), as well as patients with tonsillitis, were not included in the study.

The main complaints made by children are reflected in table. 1.

As can be seen from the table, the main complaints presented by children were pain, soreness and/or itching in the throat. Approximately half of the children had other signs of acute respiratory infection (runny nose, coughing). 10 children (31.3%) had a rise in body temperature (maximum up to 37.8°C), and 8 (25%) had general malaise. Sleep disturbance and loss of appetite were observed in isolated cases.

Pharyngoscopy revealed more or less pronounced hyperemia of the mucous membrane of the anterior palatine arches and the posterior pharyngeal wall in all children. Swelling and hyperemia of the lateral ridges of the pharynx were observed in 7 (21.9%) patients. In 5 (15.6%) patients, pronounced inflammatory phenomena were observed.

All children underwent the following course of conservative treatment with local anti-inflammatory drugs.

• Gargling with a 1% solution of chlorophyllipt 3 times a day.
• Irrigation of the pharynx with hexoral solution, 2 doses 2 times a day.
• Resorption of pharyngosept tablets, 1 tablet 3 times a day.

The duration of treatment was 7 days.

The effectiveness of treatment was assessed on the 4th and 7th days after the start of therapy. The criteria for the effectiveness of treatment were the following indicators:

• cessation of complaints;
• normalization of the pharyngoscopy picture;
• good drug tolerance.

The results of the treatment are presented in table. 2.

From the presented data it is clear that on the 4th day after the start of the course of treatment, complaints ceased in more than half of the patients (56.3%), the pharyngoscopic picture returned to normal in 12 patients (37.5%). By the end of treatment (on the 7th day), none of the children had any complaints; In all children, inflammatory manifestations in the pharynx were relieved. No adverse reactions were observed during treatment with these drugs in any of the subjects studied.

Thus, a set of conservative measures using local anti-inflammatory drugs is effective in the treatment of uncomplicated acute pharyngitis in children and allows one to avoid the use of systemic antibacterial agents.

R. Kh. Nurmukhametov, Candidate of Medical Sciences, Moscow

Note!

• Acute pharyngitis is an acute inflammation of the pharyngeal mucosa and is a common manifestation of acute respiratory diseases.
• Pharyngitis can be combined with a runny nose, cough, fever, and conjunctivitis.
• The diagnosis of pharyngitis is made based on examination of the pharynx
• The main complaints presented by children are pain, soreness and/or itching in the throat.
• Carrying out a set of conservative measures using local anti-inflammatory drugs is effective in the treatment of uncomplicated acute pharyngitis in children

Contraindications

• Individual hypersensitivity.
• Pregnancy, lactation.
• Children under 3 years old.

Information on the use of the drug during pregnancy and lactation is not provided, which does not allow us to predict whether Miramistin will have any effect on the fetus. If indicated, the use of the drug may be justified if the potential benefit to the mother outweighs the possible risk to the fetus. In this case, the drug is prescribed by a doctor. Since Miramistin is practically not absorbed and does not enter the bloodstream, the risk of negative effects on the fetus is minimal. However, due to the lack of any reliable data and studies on the use of Miramistin in pregnant women, it is not recommended to instill the solution without a doctor’s prescription.

Contraindications to the use of Miramistin for the throat in children

The use of Miramistin for the throat by children is limited only due to one absolute contraindication - increased allergic susceptibility to the constituent components of the drug.

The medicinal solution is considered one of the safest, since there is no data on negative consequences of an overdose.

Negative manifestations after topical use include only a slight tingling or burning sensation in the area of ​​the glandular epithelium affected by the infection. The symptom goes away in 25-35 seconds and does not require additional intervention.

special instructions

During treatment with Miramistin solution, it is better to refrain from wearing any types of contact lenses. It is recommended to use other methods of vision correction, since wearing contact lenses for inflammatory eye diseases can complicate treatment and lead to negative consequences. If for some reason the use of alternative methods of correction is impossible, the lenses must be removed before using the drug and put on 15 minutes after instillation.

After instillation of Miramistin solution, you should not drive or engage in potentially dangerous activities for 30 minutes.

The drug is intended for external use only. Ingestion of the medicine, as a rule, does not cause serious consequences, but can lead to nausea and the development of individual allergic reactions. In case of accidental ingestion of the product, especially by young children, it is recommended to perform gastric lavage and use enterosorbents (for example, activated carbon) according to the instructions. If any negative reactions occur, you should consult a doctor as soon as possible.

Store Miramistin solution at a temperature not exceeding +25° C. It is recommended to keep the drug in a place inaccessible to young children.

Shelf life – 3 years. Do not use after the stated expiration date.

Miramistin for the throat of a 6 month old baby

Miramistin solution for infants in the gargling format is not used. Instead, a small amount of the product (2-5 ml) is applied to a sterile medical napkin and the mucous epithelium is wiped from the inside of the cheeks, provided that the child is already six months old.

An alternative option for infants is to smear a silicone pacifier and give it to a child with a sore throat to suck on. An overdose of the drug in this case is impossible. The procedure is performed twice a day after morning and evening feeding.

Before the first use, it is recommended to conduct a skin test for allergies: drop 2 drops of the solution on the elbow or popliteal fold of the child’s body. If after a quarter of an hour a small pinkish rash, redness, and itching do not appear on the epidermis, then the medicine is used as directed.

Miramistin for gargling for children

Treatment of children's throats with an antiseptic solution is carried out in two ways:

1. Rinse undiluted (15 ml of solution twice a day).
2. Rinse with a mixture of water in a ratio of 1 to 20 (2 tsp Miramistin per 200 ml of water).

The correct rinsing procedure is as follows:

1. An amount of medicine equal to one sip is taken into the mouth.
2. The head is tilted back so that the product gets into the nasopharynx area.
3. Holding your breath through your nose, try to pronounce a long sound “y” with your throat while exhaling, for 25-30 seconds.
4. The liquid is spit into the sink.

To enhance the effect of therapeutic manipulation, rinsing with Miramistin is alternated with decoctions of medicinal herbs or soda solution.

How to dilute Miramistin for gargling for a child

For children's medicinal rinse 1 tbsp. l. Miramistin solution 0.01% is diluted in 100 ml of warm purified water. There is no need to use the entire volume of the mixture: 3-4 rinses are enough. For the new procedure, a fresh solution is prepared, and the remaining one is disposed of.

The child’s throat is treated with an aqueous solution of the drug twice a day after meals, so that the particles of the active substance remain longer on the surface of the mucous epithelium of the pharynx and larynx.

Relief from regular rinsing occurs on the 3rd day. If the symptoms of a sore throat or pharyngitis in a child persist for longer than 6-7 days, this is a reason to seek advice from a specialist.

Miramistin for the throat of a 4 year old child

From 4 years of age, it is allowed to use Miramistin solution directly through a spray nozzle to treat a child. The application goes like this:

1. Remove the nozzle installed by the manufacturer from the neck of the bottle.
2. Put on the cap with the spray mechanism so that the nozzle is at a right angle to the axis of the container.
3. Test the correct operation with 2-3 test presses directed away from the child.
4. Spray the clusters of lymphoid nodules in the child’s throat, 2 presses each.

The treatment procedure is carried out twice a day for 5-6 days. If during this time there is no improvement in the condition, and the symptoms are not eliminated, consult a therapist.

Miramistin price for throat for children

The cost of the medicine in liquid form of release of different dosages for Russia and Ukraine is presented in the table.

In Belarus and Kazakhstan, the drug is not sold in the pharmacy chain and is replaced by analogues: medicinal solutions Septomirin (7 Belarusian rubles per 100 ml) and Miraxidin (680 Tenge per 100 ml).